PARP Inhibitor VIII, PJ34

PARP Inhibitor VIII, PJ34 is a cell-permeable, water-soluble phenanthridinone derivative which inhibits of poly(ADP-ribose) polymerase (PARP; EC₅₀ = 20 nM). It is believed to be up to 10,000 times more potent than 3-aminobenzamide which has an EC = 200 μM. Studies have shown that PARP over-activation can lead to NAD depletion and consequent necrosis, thus inducing inflammatory conditions in many diseases. It has been observed that at lower concentrations, PARP Inhibitor VIII, PJ34 displays antioxidant activity. Studies conducted in vitro on stroke models indicate that this compound has neuroprotective functions. PARP Inhibitor VIII, PJ34 is an inhibitor of PARP-1 and PARP-2.