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Panobinostat

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Formula: C21H23N3O2
CAS: 404950-80-7
search Element: panobinostat
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Identification

Structural Formula
Panobinostat
CAS:
404950-80-7
EINECS:
Molecular Formula:
C21H23N3O2
MDL:
MFCD09833242
SMILES:
CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO
Synonym:
panobinostat (hdac inhibitor) ; lbh-589 ; panobinostat, >=98% ; nvp-lbh589 ; lbh-589/panobinostat ; palcociclib ; lbh589 ; panobinostat ; panobinostat (lbh589, nvp-lbh589) ; panobinostat (lbh589) ; n-hydroxy-3-[4-[2-(2-methyl-1h-indol-3-yl)ethylaminomethyl]phenyl]-2(e)-propenamide ; 2-propenamide,n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2e)-


Description

Panobinostat (LBH589) is a HDAC (histone deactylase) inhibitor of research interest for multiple diseases such as multiple myeloma. The deacetylation of histones is associated with transcriptional silencing. Panobinostat was reported to inhibit several human myeloma cell lines with IC50 ≥ 20nM. Panobinostat was also reported to induce expression of DNA damage response genes and induce apoptosis in Ph- acute lymphoblastic leukemia cells.


Suppliers

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)
CI8283312
+
Aea.ltd
A84168
+
Chemlyte Solutions
CS216648
+
Ambeed, Inc.
A165763
+
Sancai Industry Co.,Ltd.
SIC2881152
+
CSNpharm, Inc.
CSN12908
Pharmacore Co., Limited
PL276828
Zehao Industry Co., Ltd.
ZI288864
+
BOC Sciences
BS144432
+
Amadis Chemical Company Limited
ACCL3721860
+
Leap Chem Co., Ltd
LC216648
+
Santa Cruz Biotechnology, Inc.
208148
Dayang Chem (Hangzhou) Co.,Ltd.
DC3721488
+
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Manchester Organics Limited
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(2E)-N-hydroxy-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enamide
Gihi Chemicals Co., Limited
GCL33642134568

Prices & Availability




Data is processed


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Properties for Panobinostat

Molecular Weight:
349.42622 g·mol−1
Density:
1.241 g/cm3
Melting point:
114-117 °C C
Boiling point:
608.15° C (Predicted)
Solubility:
Soluble in DMSO (70 mg/ml), methanol, water (<1.2 mg/ml), DMF (~50 mg/ml), and ethanol (~3.3 mg/ml).
Physical Description:
yellow solid
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Safety & Transport Information

Storage temperature :
-20 °C Freezer, Under Inert Atmosphere
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Alternative Distributors of [Panobinostat]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Evershine Chemical Co.,Ltd. | Jinan Great Chemical Co., Ltd. | ShangHai Biochempartner Co., Ltd. | Suzhou Rovathin Pharmatech Co., Ltd | Sanowart Group Co., Ltd. | Shanghai Witofly Chemical Co., Ltd. | All Right Chemical Co., Ltd. | Suzhou Bichal Biological Technology Co., Ltd. | Langfang Bairui Pharmachem Co., Ltd. | Norn Pharmtech (Shanghai) Co., Ltd. | Sino Rarechem Labs Co. Ltd. | Mengjiangnan Chemical Co., Ltd | Gihi Chemicals Co., Limited | Clearsynth Canada INC.

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