2-Palmitoylglycerol

2-Palmitoylglycerol is a fatty acid ester, which increases the ability of 2-arachidonoylglycerol to bind to CB1 and CB2 cannabinoid receptors. Studies indicate that 2-Palmitoylglycerol also increases the inhibitory activity of 2-arachidonylglycerol on adenylyl cyclase. The inhibitory effects of 2-arachidonylglycerol on TNF α (tumor necrosis factor-α) by mouse macrophages is enhanced in the presence of 2-Palmitoylglycerol. Furthermore, 2-Palmitoylglycerol may be a key component in modulating pain sensitivity as a result of its ability to interact with endocannabinoids.