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paclitaxel

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Formula: C47H51NO14
CAS: 33069-62-4
search Element: paclitaxel

Identification

Structural Formula
paclitaxel
CAS:
33069-62-4
EINECS:
Molecular Formula:
C47H51NO14
MDL:
MFCD00869953
SMILES:
O=C1[C@H](OC(C)=O)C(C2(C)C)=C(C)[C@@H](OC([C@H](O)[C@@H](NC(C3=CC=CC=C3)=O)C4=CC=CC=C4)=O)C[C@@]2(O)[C@@H](OC(C5=CC=CC=C5)=O)[C@@]6([H])[C@@]1(C)[C@@H](O)C[C@@]7([H])OC[C@]76OC(C)=O
Synonym:
nk 105 ; taxol ; empac ; taxus ; dhp 107 ; abi 007 ; onxal ; capxol ; taxol a ; taxal


Description

Paclitaxel, discovered in 1967, is a mitotic inhibitor used in cancer chemotherapy. It is used to treat patients with lung, ovarian, breast, head and neck cancer, advanced forms of Kaposi's sarcoma, and is also used for the prevention of restenosis. Paclitaxel stabilizes microtubules and as a result, interferes with the normal breakdown of microtubules during cell division. While offering substantial improvement in patient care, paclitaxel has been a relatively controversial drug. Side effects such as unusual bruising or bleeding, pain/redness/swelling at the injection site, change in normal bowel habits for more than two days, fever, chills, cough, sore throat, difficulty swallowing, dizziness, shortness of breath, severe exhaustion, skin rash, facial flushing, female infertility by ovarian damage and chest pain can occur. Combination therapy is a new approach to take advantage of Paclitaxel's anti-cancer properties and diminish its side effects. PGA (Poly(Glutamic Acid)) is an ideal carrier to be loaded with Paclitaxel and corresponding drugs as published in the following examples: The combination of anti-angiogenic therapy with cytotoxic one offers a promising therapeutic approach. A polyglutamic acid (PGA)-Paclitaxel-E-[c(RGDfK)2] conjugate has been developed.1,2 The combination of E-[c(RGDfK)2] with Paclitaxel in the same PGA mainchain enhanced the effects previously seen for PGA-PTX alone by utilizing: (i) the additional active targeting to the avß3 integrin and (ii) its anti-angiogenic character. PGA-Paclitaxel-E-[c(RGDfK)2] displayed a potent anti-angiogenic therapy, revealed by several well-established in vitro assays. Mice bearing orthotopic mammary tumors demonstrated preferential tumor accumulation of the RGD-bearing conjugate, leading to enhanced antitumor efficacy and a marked decrease in toxicity compared with free Paclitaxel. 1,2 References: 1. A. Eldar-Boock , K. Miller, J. Sanchis, R. Lupu, M.J.Vicent, R. Satchi-Fainaro. Biomaterials 2011; 132(15): 3862-74. 2. R. Satchi-Fainaro and M.J. Vicent; WO/2009/141826 . 3. Saville, M.W.; Lietzau, J.; Pluda, J.M.; Wilson, W.H.; Humphrey, R.W.; Feigel, E.; Steinberg, S.M.; Broder, S. et al. The Lancet 1995; 346(8966): 26-8. doi:10.1016/S0140-6736(95)92654-2. 4. Ozcelik, Bulent; Turkyilmaz, Cagdas; Ozgun, Mahmut Tuncay; Serin, Ibrahim Serdar; Batukan, Cem; Ozdamar, Saim; Ozturk, Ahmet; Fertility and Sterility 2010; 93(5): 1609-14. doi:10.1016/j.fertnstert.2009.02.054.


Suppliers

Aozeal Certified Standards (AOCS), Inc.
P0077.00
Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)
CI6902760
Chengdu Pufeide Biotech. Co., Ltd
CPB3301320
Shandong Ench Chemical Co.,Ltd
SECC3001500
H&Z Industry Co.,Ltd
HIC200800
Autech Industry Co.,Limited
AIC2701080
Ambeed, Inc.
A238238
Shandong SanYoung Industry Co., Ltd
SSI3501400
Chemlyte Solutions
CS180540
Indofine Chemical Co, Inc.
06-975
JieJie Group Co., Ltd.
JG220660
Austin Chemical Company, Inc.
ACC2901160
Sinogreat Enterprise Ltd.
SE250750
X´ian Taicheng Chem Co., Ltd
XTC2901160
Shanghai Worldyang Chemical Co., Ltd.
SWC3701480
Sancai Industry Co.,Ltd.
SIC240960
Hainan Zhongxin Chemical Co., Ltd.
HZC3401360
Aecochem Corp.
AC140420
CSNpharm, Inc.
CSN19486
Hangzhou Keying Chem Co., Ltd.
HKC3001200
Hangzhou Lingrui Chemical Co., Ltd.
HLC3501400
Wanko Chemical Co., Ltd.
WC240720
Sigma-Aldrich International GmbH
SI320960
scienTEST - bioKEMIX GmbH
S-B2501000
Finetech Industry Limited
FIL2501000
Acinopeptide Co., Ltd.
A220440
Hefei Hirisun Pharmatech Co., Ltd
HR012370
Iris Biotech GmbH
LS-1047
AK Scientific, Inc.
AS190570
Xingrui Industry Co., Limited
XIL2901160
BOC Sciences
BS120360
Leap Chem Co., Ltd
LC180540
Chemos GmbH & Co. KG
CC200600
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Prices & Availability




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Properties for paclitaxel

Molecular Weight:
853.91 g·mol−1
Density:
1.40 g/cm3
Melting point:
213 °C (dec.)(lit.)
Boiling point:
957.12° C at 760 mmHg
Solubility:
methanol: 50 mg/mL, clear, colorless
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Safety & Transport Information

Risk Codes:
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed
R37/38 - Irritating to respiratory system and skin
R40 - Limited evidence of a carcinogenic effect
R41 - Risk of serious damage to eyes
R42/43 - May cause sensitization by inhalation and skin contact
R48 - Danger of serious damage to health by prolonged exposure
R62 - Possible risk of impaired fertility
R68 - Possible risk of irreversible effects
R68/20/21/22 - Harmful: possible risk of irreversible effects through inhalation, in contact with skin and if swallowed
Safety Codes:
S22 - Do not breathe dust
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
Hazard Classes:
6.1(b)
Hazard Symbols:
Xn
Hazard symbol Xn
Storage temperature :
2-8°C
RID/ADR certification :
1544
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Alternative Distributors of [paclitaxel]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Inter-Chemical Ltd. | YHEDC (Yi Heng Enterprises Development Co.) | Tai Hua Industries Co., Limited | Molekula GmbH | HuaiBei SanHe Developing Co., Ltd. | CCS. CHEM. Co., Ltd. | 3B Scientific Corporation | Shanghai Eagle Chemical Co., Ltd. | Discovery Fine Chemicals Limited | Afine Chemicals Limited | Xiang Ding Chemical International Co., Ltd | Nantong Chem-Tech. (Group) Co., Ltd. | Vesino Industrial Co., Ltd. | Nanchang Da Feng Industry Co., Ltd. | Xingcheng Chempharm Co., Ltd. | Toptechlab Pharmaceutical Co., Ltd. | Pharmasi Chemicals Co., Ltd. | TCI Europe NV | Ningbo Yuanfang Biochemicals Co., Ltd. | China Yangzhou Wandong Medical Co., Ltd. | Tianjin Pharmacn Medical Technology Co., Ltd. | Ningbo Medicn Pharmaceutical Co., Ltd. | Taizhou Bolon Pharmachem Co.,Ltd.. / Bolon Pharm & Chem Co., Ltd. | Shanghai Henghe Pharma-Tech Co., Ltd. | Abtonsmart Chemicals Co., Ltd. | New Dragon Industrial Co., Ltd | Zhejiang Esun Chemical Co., Ltd. | ShangHai Biochempartner Co., Ltd. | Shanghai Tauto Biotech Co., Ltd. | Hangzhou Onicon Chemical Co., Ltd. | Hangzhou Hysen Pharma Co., Ltd. | Chengdu Qiaofeng Technological Development Co., Ltd. | Shanghai Yingxuan Chempharm Co., Ltd. | Shanghai AOKChem Group Limited | Suzhou Rovathin Pharmatech Co., Ltd | Shanghai Richem International Co., Ltd. | Ningbo Haishu Hobid Imp & Exp Co., Ltd. | Shanghai Brightol International Co., Ltd. | Ventuschem Trading Limited | Hangzhou Pharma & Chem Co. Ltd. | Lanospharma Laboratories Co., Ltd. | Jiaxing Barton Chemicals Inc | Xi´an Sanwei Bio-Technology Co., Ltd. | China Risesun Group Co., Ltd. | TCS INDUSTRY LTD. | Win-Win Chemical Co., Limited | Jinan Great Chemical Co., Ltd. | Nantong Wanrong International Trading Co., Ltd. | Bichem Lab Co., Ltd. | Hangzhou Holypharm Biotech Co., Ltd. | East Chemical Industry Co., Ltd. | Suchem Pharma Co., Ltd. | Zhejiang Kaili Industrial Co., Ltd. | API Vanguard | Hubei Yuancheng Saichuang Tech.Co.,Ltd | Taizhou Creating Chemical Co., Ltd. | Chengdu Conut Intl. Co., Ltd. | Cfm Oskar Tropitzsch GmbH | BioBioPha Co., Ltd. | Watson International Ltd | Greenlife Biotechnology Co.,Ltd. | BOC Sciences | Scandinavian Formulas, Inc. | Sunbow Biotech Ltd. | All Right Chemical Co., Ltd. | Jinan Haohua Industry Co., Ltd. | Shanxi Jinjin Chemical Co., Ltd. | Suzhou Vosun Chemical Co.,Ltd. | Xiamen Hisunny Chemical Co., Ltd. | scienTEST | Gihi Chemicals Co., Limited | Clearsynth Canada INC. | Wanko Chemical Co., Ltd. | Haihang Industry Co., Ltd.

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