paclitaxel | CAS 33069-62-4 | Chemical-Suppliers

Element: paclitaxel

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C-S » Chemicals » paclitaxel-PX158399

Identification

paclitaxel

CAS:

33069-62-4

EINECS:

Molecular Formula:

C₄₇H₅₁NO₁₄

MDL:

MFCD00869953

SMILES:

O=C1[C@H](OC(C)=O)C(C2(C)C)=C(C)[C@@H](OC([C@H](O)[C@@H](NC(C3=CC=CC=C3)=O)C4=CC=CC=C4)=O)C[C@@]2(O)[C@@H](OC(C5=CC=CC=C5)=O)[C@@]6([H])[C@@]1(C)[C@@H](O)C[C@@]7([H])OC[C@]76OC(C)=O

Synonym:

nk 105 ; taxol ; empac ; taxus ; dhp 107 ; abi 007 ; onxal ; capxol ; taxol a ; taxal

Description

Paclitaxel, discovered in 1967, is a mitotic inhibitor used in cancer chemotherapy. It is used to treat patients with lung, ovarian, breast, head and neck cancer, advanced forms of Kaposi's sarcoma, and is also used for the prevention of restenosis. Paclitaxel stabilizes microtubules and as a result, interferes with the normal breakdown of microtubules during cell division. While offering substantial improvement in patient care, paclitaxel has been a relatively controversial drug. Side effects such as unusual bruising or bleeding, pain/redness/swelling at the injection site, change in normal bowel habits for more than two days, fever, chills, cough, sore throat, difficulty swallowing, dizziness, shortness of breath, severe exhaustion, skin rash, facial flushing, female infertility by ovarian damage and chest pain can occur. Combination therapy is a new approach to take advantage of Paclitaxel's anti-cancer properties and diminish its side effects. PGA (Poly(Glutamic Acid)) is an ideal carrier to be loaded with Paclitaxel and corresponding drugs as published in the following examples: The combination of anti-angiogenic therapy with cytotoxic one offers a promising therapeutic approach. A polyglutamic acid (PGA)-Paclitaxel-E-[c(RGDfK)2] conjugate has been developed.1,2 The combination of E-[c(RGDfK)2] with Paclitaxel in the same PGA mainchain enhanced the effects previously seen for PGA-PTX alone by utilizing: (i) the additional active targeting to the avß3 integrin and (ii) its anti-angiogenic character. PGA-Paclitaxel-E-[c(RGDfK)2] displayed a potent anti-angiogenic therapy, revealed by several well-established in vitro assays. Mice bearing orthotopic mammary tumors demonstrated preferential tumor accumulation of the RGD-bearing conjugate, leading to enhanced antitumor efficacy and a marked decrease in toxicity compared with free Paclitaxel. 1,2 References: 1. A. Eldar-Boock , K. Miller, J. Sanchis, R. Lupu, M.J.Vicent, R. Satchi-Fainaro. Biomaterials 2011; 132(15): 3862-74. 2. R. Satchi-Fainaro and M.J. Vicent; WO/2009/141826 . 3. Saville, M.W.; Lietzau, J.; Pluda, J.M.; Wilson, W.H.; Humphrey, R.W.; Feigel, E.; Steinberg, S.M.; Broder, S. et al. The Lancet 1995; 346(8966): 26-8. doi:10.1016/S0140-6736(95)92654-2. 4. Ozcelik, Bulent; Turkyilmaz, Cagdas; Ozgun, Mahmut Tuncay; Serin, Ibrahim Serdar; Batukan, Cem; Ozdamar, Saim; Ozturk, Ahmet; Fertility and Sterility 2010; 93(5): 1609-14. doi:10.1016/j.fertnstert.2009.02.054.

Suppliers

Ambeed, Inc.

A238238

Shandong SanYoung Industry Co., Ltd

SSI3501400

Chemlyte Solutions

CS180540

Aozeal Certified Standards (AOCS), Inc.

P0077.00

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI6902760

Chengdu Pufeide Biotech. Co., Ltd

CPB3301320

Shandong Ench Chemical Co.,Ltd

SECC3001500

H&Z Industry Co.,Ltd

HIC200800

Autech Industry Co.,Limited

AIC2701080

Indofine Chemical Co, Inc.

06-975

JieJie Group Co., Ltd.

JG220660

Austin Chemical Company, Inc.

ACC2901160

Sinogreat Enterprise Ltd.

SE250750

X´ian Taicheng Chem Co., Ltd

XTC2901160

Shanghai Worldyang Chemical Co., Ltd.

SWC3701480

Sancai Industry Co.,Ltd.

SIC240960

Hainan Zhongxin Chemical Co., Ltd.

HZC3401360

Aecochem Corp.

AC140420

CSNpharm, Inc.

CSN19486

Hangzhou Keying Chem Co., Ltd.

HKC3001200

Hangzhou Lingrui Chemical Co., Ltd.

HLC3501400

Wanko Chemical Co., Ltd.

WC240720

Sigma-Aldrich International GmbH

SI320960

scienTEST - bioKEMIX GmbH

S-B2501000

Finetech Industry Limited

FIL2501000

Acinopeptide Co., Ltd.

A220440

Hefei Hirisun Pharmatech Co., Ltd

HR012370

Iris Biotech GmbH

LS-1047

AK Scientific, Inc.

AS190570

Xingrui Industry Co., Limited

XIL2901160

BOC Sciences

BS120360

Leap Chem Co., Ltd

LC180540

Chemos GmbH & Co. KG

CC200600

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Prices & Availability

Data is processed

Properties for paclitaxel

Molecular Weight:

853.91 g·mol−1

Density:

1.40 g/cm³

Melting point:

213 °C (dec.)(lit.)

Boiling point:

957.12° C at 760 mmHg

Solubility:

methanol: 50 mg/mL, clear, colorless

Safety & Transport Information

Risk Codes:

R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed
R37/38 - Irritating to respiratory system and skin
R40 - Limited evidence of a carcinogenic effect
R41 - Risk of serious damage to eyes
R42/43 - May cause sensitization by inhalation and skin contact
R48 - Danger of serious damage to health by prolonged exposure
R62 - Possible risk of impaired fertility
R68 - Possible risk of irreversible effects
R68/20/21/22 - Harmful: possible risk of irreversible effects through inhalation, in contact with skin and if swallowed

Safety Codes:

S22 - Do not breathe dust
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)

Hazard Classes:

6.1(b)

Hazard Symbols:

Storage temperature :

2-8°C

RID/ADR certification :

1544

Alternative Distributors of [paclitaxel]

Producers or manufacturers change the product range from time to time. The following companies
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