Description
Paclitaxel, discovered in 1967, is a mitotic inhibitor used in cancer chemotherapy. It is used to treat patients with lung, ovarian, breast, head and neck cancer, advanced forms of Kaposi's sarcoma, and is also used for the prevention of restenosis. Paclitaxel stabilizes microtubules and as a result, interferes with the normal breakdown of microtubules during cell division. While offering substantial improvement in patient care, paclitaxel has been a relatively controversial drug. Side effects such as unusual bruising or bleeding, pain/redness/swelling at the injection site, change in normal bowel habits for more than two days, fever, chills, cough, sore throat, difficulty swallowing, dizziness, shortness of breath, severe exhaustion, skin rash, facial flushing, female infertility by ovarian damage and chest pain can occur. Combination therapy is a new approach to take advantage of Paclitaxel's anti-cancer properties and diminish its side effects. PGA (Poly(Glutamic Acid)) is an ideal carrier to be loaded with Paclitaxel and corresponding drugs as published in the following examples: The combination of anti-angiogenic therapy with cytotoxic one offers a promising therapeutic approach. A polyglutamic acid (PGA)-Paclitaxel-E-[c(RGDfK)2] conjugate has been developed.1,2 The combination of E-[c(RGDfK)2] with Paclitaxel in the same PGA mainchain enhanced the effects previously seen for PGA-PTX alone by utilizing: (i) the additional active targeting to the avß3 integrin and (ii) its anti-angiogenic character. PGA-Paclitaxel-E-[c(RGDfK)2] displayed a potent anti-angiogenic therapy, revealed by several well-established in vitro assays. Mice bearing orthotopic mammary tumors demonstrated preferential tumor accumulation of the RGD-bearing conjugate, leading to enhanced antitumor efficacy and a marked decrease in toxicity compared with free Paclitaxel. 1,2 References: 1. A. Eldar-Boock , K. Miller, J. Sanchis, R. Lupu, M.J.Vicent, R. Satchi-Fainaro. Biomaterials 2011; 132(15): 3862-74. 2. R. Satchi-Fainaro and M.J. Vicent; WO/2009/141826 . 3. Saville, M.W.; Lietzau, J.; Pluda, J.M.; Wilson, W.H.; Humphrey, R.W.; Feigel, E.; Steinberg, S.M.; Broder, S. et al. The Lancet 1995; 346(8966): 26-8. doi:10.1016/S0140-6736(95)92654-2. 4. Ozcelik, Bulent; Turkyilmaz, Cagdas; Ozgun, Mahmut Tuncay; Serin, Ibrahim Serdar; Batukan, Cem; Ozdamar, Saim; Ozturk, Ahmet; Fertility and Sterility 2010; 93(5): 1609-14. doi:10.1016/j.fertnstert.2009.02.054.
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Alternative Distributors of [paclitaxel]
Producers or manufacturers change the product range from time to time.
The following companies
have appeared as suppliers in the past / currently not verified
Inter-Chemical Ltd. | YHEDC (Yi Heng Enterprises Development Co.) | Tai Hua Industries Co., Limited | Molekula GmbH | HuaiBei SanHe Developing Co., Ltd. | CCS. CHEM. Co., Ltd. | 3B Scientific Corporation | Shanghai Eagle Chemical Co., Ltd. | Discovery Fine Chemicals Limited | Afine Chemicals Limited | Xiang Ding Chemical International Co., Ltd | Nantong Chem-Tech. (Group) Co., Ltd. | Vesino Industrial Co., Ltd. | Nanchang Da Feng Industry Co., Ltd. | Xingcheng Chempharm Co., Ltd. | Toptechlab Pharmaceutical Co., Ltd. | Pharmasi Chemicals Co., Ltd. | TCI Europe NV | Ningbo Yuanfang Biochemicals Co., Ltd. | China Yangzhou Wandong Medical Co., Ltd. | Tianjin Pharmacn Medical Technology Co., Ltd. | Ningbo Medicn Pharmaceutical Co., Ltd. | Taizhou Bolon Pharmachem Co.,Ltd.. / Bolon Pharm & Chem Co., Ltd. | Shanghai Henghe Pharma-Tech Co., Ltd. | Abtonsmart Chemicals Co., Ltd. | New Dragon Industrial Co., Ltd | Zhejiang Esun Chemical Co., Ltd. | ShangHai Biochempartner Co., Ltd. | Shanghai Tauto Biotech Co., Ltd. | Hangzhou Onicon Chemical Co., Ltd. | Hangzhou Hysen Pharma Co., Ltd. | Chengdu Qiaofeng Technological Development Co., Ltd. | Shanghai Yingxuan Chempharm Co., Ltd. | Shanghai AOKChem Group Limited | Suzhou Rovathin Pharmatech Co., Ltd | Shanghai Richem International Co., Ltd. | Ningbo Haishu Hobid Imp & Exp Co., Ltd. | Shanghai Brightol International Co., Ltd. | Ventuschem Trading Limited | Hangzhou Pharma & Chem Co. Ltd. | Lanospharma Laboratories Co., Ltd. | Jiaxing Barton Chemicals Inc | Xi´an Sanwei Bio-Technology Co., Ltd. | China Risesun Group Co., Ltd. | TCS INDUSTRY LTD. | Win-Win Chemical Co., Limited | Jinan Great Chemical Co., Ltd. | Nantong Wanrong International Trading Co., Ltd. | Bichem Lab Co., Ltd. | Hangzhou Holypharm Biotech Co., Ltd. | East Chemical Industry Co., Ltd. | Suchem Pharma Co., Ltd. | Zhejiang Kaili Industrial Co., Ltd. | API Vanguard | Hubei Yuancheng Saichuang Tech.Co.,Ltd | Taizhou Creating Chemical Co., Ltd. | Chengdu Conut Intl. Co., Ltd. | Cfm Oskar Tropitzsch GmbH | BioBioPha Co., Ltd. | Watson International Ltd | Greenlife Biotechnology Co.,Ltd. | BOC Sciences | Scandinavian Formulas, Inc. | Sunbow Biotech Ltd. | All Right Chemical Co., Ltd. | Jinan Haohua Industry Co., Ltd. | Shanxi Jinjin Chemical Co., Ltd. | Suzhou Vosun Chemical Co.,Ltd. | Xiamen Hisunny Chemical Co., Ltd. | scienTEST | Gihi Chemicals Co., Limited | Clearsynth Canada INC. | Wanko Chemical Co., Ltd. | Haihang Industry Co., Ltd.