Identification
OSI-420, Free Base (Desmethyl Erlotinib)
Molecular Formula:
C2 1 H2 1 N3 O4
SMILES:
COCCOC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCO
Synonym:
Ethanol, 2-[[4-[(3-ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl]oxy]-
Description
OSI-420 is a metabolite of Erlotinib. Erlontinib potently inhibits EGFR autophosphorylation in cultured human head and neck tumor cells, a cell line which exhibits high levels of EGFR. Erlotinib also inhibits the proliferation of PC-9 cell lines, which contain a deletion mutation on exon 19 of the EGFR gene. A combination of Erlotinib and rapamycin produced a synergistic inhibitory effect on cell growth.
Suppliers
Santa Cruz Biotechnology, Inc.
212485
CAS equal suppliers
OSI-420
Excenen Pharmatech Co., Ltd.
EX-A064-1
CP 373420
Chemieliva Pharmaceutical Co., Ltd.
CP315945
CP 373420
Leap Chem Co., Ltd
LC162486
CP 373420
Dayang Chem (Hangzhou) Co.,Ltd.
DC2791116
CP 373420
Finipharma Ltd
F126252
CP 373420
ShangHai Biochempartner Co., Ltd.
BCP02398
Desmethyl erlotinib
Salsbury Chemicals, Inc.
SC9122736
Desmethyl erlotinib
BOC Sciences
BS4561368
Erlotinib O-Desmethyl Metabolite (M14)
Pharmaffiliates Analytics & Synthetics Pvt. Limited
PA 05 14510
2-({4-[(3-Ethynylphenyl)amino]-7-(2-methoxyethoxy)quinazolin-6-yl}oxy)ethan-1-ol
Chemlyte Solutions
CS1728051840
Prices & Availability
Data is processed
Properties
Safety & Transport
Alternative Distributors
Downloads
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Properties for OSI-420, Free Base (Desmethyl Erlotinib)
Molecular Weight:
379.41 g·mol−1
Density:
1.31 g/cm3 (Predicted)
Melting point:
140-142° C
Boiling point:
572.81° C at 760 mmHg (Predicted)
Solubility:
Soluble in methanol, and DMSO.
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Safety & Transport Information
coming up soon
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Alternative Distributors of [OSI-420, Free Base (Desmethyl Erlotinib)]
Producers or manufacturers change the product range from time to time.
Currently there are no other manufacturers known.
Element: 
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