Orexin A (human, bovine, canine, mouse, ovine, porcine, rat) acetate salt; Sequence: [Cys4-Cys12,Cys7-Cys14] pEPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2 acetate salt

Orexin A (hypocretin-1) is a hypothalamic neuropeptide regulating the feeding behavior. Central administration of orexin A to rats stimulated food consumption in a dose-dependent manner. The effect persisted at 4 h after injection, as orexin A seems to be resistant to peptidases. Orexin A specifically binds a G protein-coupled receptor, OX1R (IC50 = 20 nM to displace 50 % of radiolabeled orexin A bound to this receptor). Orexin A produced in the amygdala induces wakefulness and plays a role in the induction of human emotions. Narcolepsy has been associated with orexin deficiency. References: A.M.Blouin et al.; Nat. Commun. 2013; 4: 1547. E.Göncz et al.; Endocrinology 2008; 149: 1618. M.R.Jain et al.; Regul. Peptides 2000; 87: 19. T.Sakurai et al.; Cell 1998; 92: 573. M.W.Schwartz; Nat. Med. 1998; 4: 385.