Omi/HtrA2 Protease Inhibitor, Ucf-101 | CAS 313649-08-0

Element: inhibitor protease htra2

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C-S » Chemicals » omi-htra-protease-inhibitor-ucf-PX76374

Identification

Omi/HtrA2 Protease Inhibitor, Ucf-101

CAS:

313649-08-0

EINECS:

Molecular Formula:

C₂₇H₁₇N₃O₅S

MDL:

MFCD01000361

SMILES:

C1(=C(C=CC=C1)N(O)O)C2=CC=C(O2)C=C3C(N(C(N(C3=O)C4=CC=CC=C4)=S)C5=CC=CC=C5)=O

Synonym:

Description

Omi/HtrA2 Protease Inhibitor, Ucf-101 is a cell-permeable furfurylidine-thiobarbituric acid compound that acts as a potent, specific, competitive, and reversible inhibitor of the pro-apoptotic, heat-inducible, mitochondrial serine protease Omi/HtrA2 (IC₅₀ = 9.5 μM for His-Omi_134-458). Shows very little activity against various other serine proteases tested (IC₅₀ ≥ 200 μM). Reported to block Omi/HtrA2 induced cell death in caspase-9 (-/-) null fibroblasts.

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Santa Cruz Biotechnology, Inc.

222101

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Properties for Omi/HtrA2 Protease Inhibitor, Ucf-101

Molecular Weight:

495.5 g·mol−1

Density:

~1.50 g/cm³ (Predicted)

Solubility:

Soluble in DMSO (5 mg/ml).

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Alternative Distributors of [Omi/HtrA2 Protease Inhibitor, Ucf-101]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.

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Mol File:

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MSDS:

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