N-Oleoyldopamine (OLDA) is an endogenous lipid compund in the mammalian brain. It has been found to be a VR1 (TRPV1) activator and potent 5-LO inhibitor. Activation of the VR1 receptor induces glutamate release and paraventricular nucleus postsynaptic firing. OLDA has been reported to induce the influx of calcium in VR1-transfected human embryonic kindey 293 cells. It has also been reported to induce the accumulation of cAMP in GPR119-transfected cells. OLDA has been also been observed to stimulate the release of insulin in HIT-T15 cells that endogenously express GPR119.