Nutlin-3 | CAS 548472-68-0 | Chemical-Suppliers

Element: nutlin

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C-S » Chemicals » nutlin-PX77161

Identification

Nutlin-3

CAS:

548472-68-0

EINECS:

Molecular Formula:

C₃₀H₃₀Cl₂N₄O₄

MDL:

MFCD07784509

SMILES:

CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

Synonym:

Description

Nutlin-3, the racemic and most commonly used form of nutlin, inhibits p53-MDM2 interaction. It has shown ability to induce the expression of p53-regulated genes and exhibits potent antiproliferative activity in cells with functional p53, but not in cells with mutated p53. When in combination with perifosine, anti-leukaemic activity has been observed. High N-MYC (MycN) expression has been induced in non-N-MYC-amplified neuroblastoma cells when treated with the combination of nutlin-3 and doxorubicin.

Suppliers

Aea.ltd

A56112

BOC Sciences

BS96288

Amadis Chemical Company Limited

ACCL2481240

Leap Chem Co., Ltd

LC144432

Santa Cruz Biotechnology, Inc.

45061

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CAS equal suppliers

Nutlin 3

Ambeed, Inc.

A140511

Nutlin 3

CSNpharm, Inc.

CSN18807

(�)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one

BLD Pharmatech Ltd

BP2714481432

Prices & Availability

Data is processed

Properties for Nutlin-3

Molecular Weight:

581.49 g·mol−1

Density:

1.36 g/cm³ (Predicted)

Solubility:

Soluble in ethanol (25 mg/ml), DMSO (20 mg/ml), DMF, methanol, and acetonitrile. Insoluble in water. Sparingly soluble in ethanol:PBS pH 7.2 (1:10).

Safety & Transport Information

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Alternative Distributors of [Nutlin-3]

Producers or manufacturers change the product range from time to time. The following companies
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