Novobiocin Sodium Salt | CAS 1476-53-5

Element: novobiocin sodium salt

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C-S » Chemicals » novobiocin-sodium-salt-PX95206

Identification

Novobiocin Sodium Salt

CAS:

1476-53-5

EINECS:

216-023-6

Molecular Formula:

C₃₁H₃₅N₂NaO₁₁

MDL:

MFCD00066541

SMILES:

CC1=C(C=CC2=C1OC(=O)C(=C2[O-])NC(=O)C3=CC(=C(C=C3)O)CC=C(C)C)OC4C(C(C(C(O4)(C)C)OC)OC(=O)N)O.[Na+]

Synonym:

nsc 2382 ; u-6591 ; albamycinsodium ; albamycin ; vulcamycin ; albycin sodium ; albadry ; streptonivicin ; robicina ; sodiumalbamycin

Description

Novobiocin Sodium (U-6591) is a small molecule inhibitor of eukaryotic Topo II (DNA topoisomerase II) and prokaryotic DNA gyrase. In the case of DNA gyrase inhibition, Novobiocin functions as a competitive inhibitor of the ATP binding event necessary for turnover of the enzyme after a manipulation of DNA supercoils. Inhibition of these enzymes blocks the mechanism for detangling DNA and establishing the proper super-coiled state necessary for normal replication and transcription, compromising the viability of the cell. Treatment with Novobiocin is shown to potentiate the cytotoxic effects of DNA alkylating agents. Novobiocin is also described to inhibit DNA Polymerase (retroviral RNA-dependent DNA polymerase). Novobiocin is an inhibitor of Hsp90. Novobiocin interacts with the C-terminal ATP-binding domain of Hsp90. Novobiocin Sodium (U-6591) is an inhibitor of ABCG2.

Suppliers

Nantong Xindao Biotech Ltd

NXB17166864

Indofine Chemical Co, Inc.

Bio-311

Alfa (A Johnson Matthey Company)

A21126336

Xiamen Equation Chemical Co.,Ltd

XECC211210560

Sigma-Aldrich International GmbH

SI21126336

scienTEST - bioKEMIX GmbH

S-B16506600

Santa Cruz Biotechnology, Inc.

358734

Dayang Chem (Hangzhou) Co.,Ltd.

DC20468184

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CAS equal suppliers

Novobiocin sodium

Leap Chem Co., Ltd

LC6121836

Novobiocin sodium

ShangHai Biochempartner Co., Ltd.

BCP14372

Novobiocin Sodium

CSNpharm, Inc.

CSN11583

Novobiocin sodium

Wuhan PharmChem Co., LTD.

WP8502550

Novobiocin Sodium (U-6591)

Santa Cruz Biotechnology, Inc.

sc-358734

Sodium 4-((7-(((2R,3R,4S,5R)-4-(carbamoyloxy)-3-hydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-8-methyl-2-oxo-2H-chromen-3-yl)carbamoyl)-2-(3-methylbut-2-en-1-yl)phenolate

BLD Pharmatech Ltd

BP104760314280

Prices & Availability

Data is processed

Properties for Novobiocin Sodium Salt

Molecular Weight:

634.61 g·mol−1

Melting point:

215-220 C

Solubility:

Soluble in water (100 mg/ml), ethanol, DMSO, alcohol (1:7), and methanol (1:3).

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:

R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed
R36 - Irritating to eyes
R36/37/38 - Irritating to eyes, respiratory system and skin
R43 - May cause sensitisation by skin contact

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
S36/37 - Wear suitable protective clothing and gloves
S37/39 - Wear suitable gloves and eye/face protection

Hazard Symbols:

Xi, Xn

Storage temperature :

2-8°C

Alternative Distributors of [Novobiocin Sodium Salt]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

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Mol File:

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MSDS:

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