8-Nitroguanine | CAS 168701-80-2

Element: nitroguanine

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C-S » Chemicals » nitroguanine-PX64325

Identification

8-Nitroguanine

CAS:

168701-80-2

EINECS:

Molecular Formula:

C₅H₄N₆O₃

MDL:

MFCD02259372

SMILES:

C12=C(NC(=NC1=O)N)N=C(N2)[N+](=O)[O-]

Synonym:

8-nitroguanine-4,8-13c2-7-15n ; 2-amino-8-nitro-1,7-dihydro-6h-purin-6-one ; 8-no2-gua ; 2-amino-1,9-dihydro-8-nitro- ; 8-nitroguanine

Description

8-Nitroguanine is a potent mutagenic product of DNA formed during inflammation. Specifically, it is the result of a GC to AT induced transversion mutation from the guanine base of DNA. The compound plays an important role in inflammation-related carcinogenesis. Research shows that it has the potential as a biomarker to evaluate carcinogensis and tumor progression.