Nicotinamide 1,N6-ethenoadenine dinucleotide | CAS 38806-38-1

Element: ethenoadenine dinucleotide nicotinamide

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C-S » Chemicals » nicotinamide-ethenoadenine-dinucleotide-PX81715

Identification

Nicotinamide 1,N6-ethenoadenine dinucleotide

CAS:

38806-38-1

EINECS:

Molecular Formula:

C₂₃H₂₇ N₇ O₁₄ P₂

MDL:

MFCD00063546

SMILES:

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C4N=CN6C5=NC=C6)O)O)O)O)C(=O)N

Synonym:

3H-Imidazo[2,1-i]purine,pyridinium deriv. ; 1,N6-Ethenonicotinamide adenine dinucleotide ; Nicotinamide1,N6-ethenoadenine dinucleotide ; e-NAD ; Pyridinium,3-(aminocarbonyl)-1-[5-O-[hydroxy(phosphonooxy)phosphinyl]-b-D-ribofuranosyl]-, inner salt,P'® ; 5'-ester with 3-b-D-ribofuranosyl-3H-imidazo[2,1-i]purine

Description

Nicotinamide 1,N6-ethenoadenine is an analog of β-NAD which can act as a fluorescent tag in nucleotide binary and ternary complex formation tests. The ADP-ribose moiety from NAD Free Acid and its analogs can be transferred to proteins and protein-bound ADP-ribose by PARP-1 (ADP Poly(ADP-ribosyl) transferase, pADPRT). These studies show that NAD⁺ is a better substrate in polymer synthesis reactions than Nicotinamide 1,N6-ethenoadenine. In addition, polyacrylamide gels show that proteins bound with ADP-ribose from Nicotinamide 1,N6-ethenoadenine show slower motility through the gel. This study suggests that Nicotinamide 1,N6-ethenoadenine is useful for studying enzymes degrading poly(ADP-ribose) as a result of this compounds fluorescent nature.

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Properties for Nicotinamide 1,N6-ethenoadenine dinucleotide

Molecular Weight:

687.45 g·mol−1

Solubility:

Soluble in water (250 mg/ml).

Safety & Transport Information

Risk Codes:

R36/37/38 - Irritating to eyes, respiratory system and skin

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing

Hazard Symbols:

Alternative Distributors of [Nicotinamide 1,N6-ethenoadenine dinucleotide]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.

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Mol File:

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MSDS:

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