Nicorandil | CAS 65141-46-0 | Chemical-Suppliers

Element: nicorandil

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C-S » Chemicals » nicorandil-PX76884

Identification

Nicorandil

CAS:

65141-46-0

EINECS:

265-514-1

Molecular Formula:

C₈H₉N₃O₄

MDL:

MFCD00186520

SMILES:

[O-][N+](=O)OCCNC(=O)C1=CN=CC=C1

Synonym:

Description

Nicorandil is a small molecule KATP (Kir6) channel opener, producing relaxation of coronary vascular smooth muscle. Specific binding of Nicorandil to the C-terminus of the SUR2B K(ATP) channel generates K⁺ flux and hyperpolarization of the surface membrane, producing consequent closure of voltage-dependent ion channels and reduction of intracellular free Ca²⁺. Nicorandil stimulates guanylate cyclase and increases cyclic GMP levels in correlation with the activation of K(ATP) channels. Nicorandil is also described to suppress mitochondrial permeability transition triggered by oxidative stress resulting from ischemia-reperfusion, preventing mitochondrial calcium uptake/overload and oxidative damage. Nicorandil has also been shown to serve as a nitric oxide donor.

Suppliers

Chemlyte Solutions

CS180540

Ambeed, Inc.

A957622

Aozeal Certified Standards (AOCS), Inc.

N0017.00

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI6902760

Xiamen Equation Chemical Co.,Ltd

XECC3201600

CSNpharm, Inc.

CSN12869

Hangzhou Lingrui Chemical Co., Ltd.

HLC3501400

Finetech Industry Limited

FIL2501000

Simagchem Corporation

SC210630

Xingrui Industry Co., Limited

XIL2901160

Capot Chemical Co., Ltd.

27189

Amadis Chemical Company Limited

ACCL3101550

Leap Chem Co., Ltd

LC180540

Santa Cruz Biotechnology, Inc.

200995

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CAS equal suppliers

Nicorandil-d4

Santa Cruz Biotechnology, Inc.

sc-219354

Nicorandil, 98+%

Alfa (A Johnson Matthey Company)

A5121536

[2-(Pyridin-3-ylformamido)ethyl] nitrate

AK Scientific, Inc.

AS380011400

3-Pyridinecarboxamide, n-[2-(nitrooxy)ethyl]-

Angene International Limited

AGN-PC-050KZZ

Prices & Availability

Data is processed

Properties for Nicorandil

Molecular Weight:

211.17 g·mol−1

Density:

1.3 g/cm³ (Predicted)

Melting point:

92-93° C

Boiling point:

456.7° C at 760 mmHg (Predicted)

Solubility:

Soluble in water (4 mg/ml), DMSO (>25 mg/ml), ethanol, ether, and methanol.

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Alternative Distributors of [Nicorandil]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Downloads

Mol File:

-/-

MSDS:

-/-

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