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Niclosamide

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Formula: C13H8Cl2N2O4
CAS: 50-65-7
search Element: niclosamide
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Identification

Structural Formula
Niclosamide
CAS:
50-65-7
EINECS:
200-056-8
Molecular Formula:
C13H8Cl2N2O4
MDL:
MFCD00057597
SMILES:
C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O
Synonym:
hl2447 ; fenasal ; b2353 ; iomesan ; iomezan ; lintex ; bay2353 ; mato ; sulqui ; nasemo


Description

Niclosamide is an inhibitor of the Stat3 signaling pathway. Niclosamide inhibits the activation, nuclear translocation and transactivation of Stat3. Niclosamide displays selectivity for Stat3 over Stat1, Stat5, JAK1, JAK2 and Src kinases. Niclosamide inhibits the transcription of Stat3 target genes and induces cell growth inhibition, apoptosis and cell cycle arrest of cancer cells with constitutively active Stat3. Niclosamide is also a FRAP inhibitor via reversible inhibition of mTORC1 signaling and stimulates autophagy in vitro. Niclosamide displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells.


Suppliers

Refine Chemical Co.,Ltd.
RCC2641056
+
Shandong Lanhai Industry Co.,Ltd.
SLIC3631815
+
H&Z Industry Co.,Ltd
HIC220880
+
Fountain Biotechnology Co.,Ltd
FBC3301320
+
OPQ Chemical Co., Ltd
OC231693
+
Autech Industry Co.,Limited
AIC2971188
+
Nantong Xindao Biotech Ltd
NXB2861144
+
Create Chemical Co., Ltd.
CC275825
+
Aozeal Certified Standards (AOCS), Inc.
N0041.00
+
Chemlyte Solutions
CS198594
+
Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)
CI7593036
+
Lori Industry Co., Ltd
LI242726
+
AXO Industry SA
AIS165660
+
IBIS Chemie International
ICI2751100
+
X´ian Taicheng Chem Co., Ltd
XTC3191276
+
Shanghai Worldyang Chemical Co., Ltd.
SWC4071628
+
Sancai Industry Co.,Ltd.
SIC2641056
+
Arakato Development Ltd
AD253759
+
Aecochem Corp.
AC154462
+
Hangzhou Keying Chem Co., Ltd.
HKC3301320
+
Hangzhou Lingrui Chemical Co., Ltd.
HLC3851540
+
Sigma-Aldrich International GmbH
SI3521056
+
Finetech Industry Limited
FIL2751100
+
Carbone Scientific Co., Ltd.
CS308924
+
Simagchem Corporation
SC231693
+
Xingrui Industry Co., Limited
XIL3191276
+
Zehao Industry Co., Ltd.
ZI264792
+
Leap Chem Co., Ltd
LC198594
+
Santa Cruz Biotechnology, Inc.
250564
Dayang Chem (Hangzhou) Co.,Ltd.
DC3411364
+
Get Quick Quote

CAS equal suppliers

Niclosamide, Pharma
Xiamen Equation Chemical Co.,Ltd
XECC12166080
5-Chloro-N-(2-chloro-4-nitrophenyl)salicylamide
AK Scientific, Inc.
AS357210716
Benzamide, 5-chloro-n-(2-chloro-4-nitrophenyl)-2-hydroxy-
Angene International Limited
AGN-PC-08WHBK

Prices & Availability




Data is processed


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Properties for Niclosamide

Molecular Weight:
327.12 g·mol−1
Density:
~1.6 g/cm3 (Predicted)
Melting point:
225-233° C
Boiling point:
~424.5° C at 760 mmHg (Predicted)
Solubility:
Soluble in ethanol (25 mM), DMSO (10 mM), chloroform (very slightly), and methanol: acetone (1: 1) (50 mg/ml). Insoluble in water.
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Safety & Transport Information

Storage temperature :
0-6°C
RID/ADR certification :
UN 3077 9 / PG 3
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Alternative Distributors of [Niclosamide]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Inter-Chemical Ltd. | Santec Chemicals Corp. | Zhejiang Changxing Zhongshan Chemical Industry Co. | Wujiang Senliang Chemical Co. Ltd. | China Jiangsu International Economic Technical Cooperation Cor. | CCS. CHEM. Co., Ltd. | Hallochem Pharma Co., Ltd. | 3B Scientific Corporation | Jiangsu Guotai International Group Co., Ltd. | Nantong Chem-Tech. (Group) Co., Ltd. | Shaanxi Hanjiang Pharmaceutical Group Co., Ltd. | Pharmasi Chemicals Co., Ltd. | Ningbo Pangs Chem Int'l Co., Ltd. | Shanghai ChemVia Co., Ltd | Shaanxi Hanjiang Pharmaceutical Group Co., Ltd. | New Dragon Industrial Co., Ltd | Chemisumo Company Limited | Chengdu Qiaofeng Technological Development Co., Ltd. | Suzhou Rovathin Pharmatech Co., Ltd | Jinan Great Chemical Co., Ltd. | Xuzhou Shennong Chemicals Co., Ltd. | Zouping Mingxing Chemical Co., Ltd. | Zhejiang Kaili Industrial Co., Ltd. | King Tang Chemical Group Industry Co., Ltd. | Watson International Ltd | BOC Sciences | Hubei Yuancheng Saichuang Tech.Co.,Ltd | Jiangsu Pengxingbo Industry Co., Ltd. | Suzhou Vosun Chemical Co.,Ltd. | Jinan Haohua Industry Co., Ltd. | Gihi Chemicals Co., Limited | Xiamen Hisunny Chemical Co., Ltd. | Nebula Chemicals Co, Ltd. | Wanko Chemical Co., Ltd.

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