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NFAT Activation Inhibitor III

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Formula: C20H12O2
CAS: 3519-82-2
search Element: activation inhibitor nfat
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Identification

Structural Formula
NFAT Activation Inhibitor III
CAS:
3519-82-2
EINECS:
Molecular Formula:
C20H12O2
MDL:
SMILES:
C1=CC=C2C3C4=CC=CC=C4C(C2=C1)C5=C3C(=O)C=CC5=O
Synonym:
9,10-dihydro-9,10[1',2']-benzenoanthracene-1,4-dione ; 9,10-dihydro-9,10-[1,2]benzeno-1,4-anthraquinone ; 9,10-[1,2]benzeno-9,10-dihydroanthracene-1,4-dione ; nfat activation inhibitor iii ; 9,10-[1,2]benzeno-1,4,9,10-tetrahydroanthracene-1,4-dione ; inca-6 ; 1,4,9,10-tetrahydro-9,10-[1,2]benzenoanthracene-1,4-dione ; nsc25996 ; 9,10-[1,2]benzeno-9,10-dihydro-1,4-anthraquinone


Description

NFAT Activation Inhibitor III (INCA-6) is a potent and selective inhibitor of calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling. A quinone based compound that is cellularly permeable and blocks NFAT dephosphorylation. In experiments, this product particularly showed ability to prevent transient outward K+ current reduction in 3-Hz paced left ventricular cardiomyocytes following tachycardia. NFAT Activation Inhibitor III does not exhibit effects on calcineurin activity or on calcineurin's downstream signaling.


Suppliers

Santa Cruz Biotechnology, Inc.
203160
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Prices & Availability




Data is processed


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Properties for NFAT Activation Inhibitor III

Molecular Weight:
284.313 g·mol−1
Density:
1.38 g/cm3 (Predicted)
Melting point:
182.66° C (Predicted)
Boiling point:
464.20° C at 760 mmHg (Predicted)
Solubility:
Soluble in ethanol (5 mg/ml), and DMSO (20 mM).
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Safety & Transport Information

Storage temperature :
Store at RT
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Alternative Distributors of [NFAT Activation Inhibitor III]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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Mol File:
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MSDS:
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