Nebivolol hydrochloride | CAS 152520-56-4

Element: hydrochloride nebivolol

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C-S » Chemicals » nebivolol-hydrochloride-PX71326

Identification

Nebivolol hydrochloride

CAS:

152520-56-4

EINECS:

Molecular Formula:

C₂₂H₂₅F₂NO₄.HCl

MDL:

MFCD07357273

SMILES:

C1CC2=C(C=CC(=C2)F)O[C@H]1[C@H](CNC[C@@H]([C@@H]3CCC4=C(O3)C=CC(=C4)F)O)O.Cl

Synonym:

lobivon ; nebilet ; narbivolol ; bystolic ; nebilox ; nebivolol hc ; r-67555 ; d06622 ; nebivolol (bystolic) ; nebivalate hcl

Description

Nebivolol hydrochloride is the hydrochloride salt preparation of Nebivolol, a highly selective antagonist of the β1-AR (β₁-adrenoceptor) (K_i = 0.88 nM, β₂-adrenoceptor K_i = 48 nM). Nebivolol is described to produce vasodilation through inducing vascular production of NO, mediated through Nebivolol agonism of the β₃-adrenoceptor. Nebivolol demonstrates some affinity at the α₁-adrenergic (K_i = 1160 nM), SR-1A (serotonin 5-HT_1A) (K_i = 20 nM) and 5-HT₂ (K_i = 700 nM), dopamine D₂ (K_i = 4000 nM), and histamine H₁ (K_i = 2400 nM) receptors.

Suppliers

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI317412696

Autech Industry Co.,Limited

AIC12424968

Ambeed, Inc.

A294376

Aozeal Certified Standards (AOCS), Inc.

N0037.00

Xiamen Equation Chemical Co.,Ltd

XECC14727360

Hangzhou Keying Chem Co., Ltd.

HKC13805520

Finetech Industry Limited

FIL11504600

AK Scientific, Inc.

AS8742622

Xingrui Industry Co., Limited

XIL13345336

Capot Chemical Co., Ltd.

18274

Santa Cruz Biotechnology, Inc.

204122

Chemos GmbH & Co. KG

CC9202760

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LP260780

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Haihang Industry Co., Ltd.

HI6762028

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Excenen Pharmatech Co., Ltd.

EN-3912

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CSNpharm, Inc.

CSN10098

Racemic Nebivolol Hydrochloride Labeled d4

Santa Cruz Biotechnology, Inc.

sc-355964

Prices & Availability

Data is processed

Properties for Nebivolol hydrochloride

Molecular Weight:

441.9 g·mol−1

Melting point:

220-222 °C

Solubility:

Soluble in water (<1 mg/ml at 25° C), ethanol (10 mM), DMSO (88 mg/ml at 25° C), methanol, and DMF.

Safety & Transport Information

Risk Codes:

R22 - Harmful if swallowed
R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment

Safety Codes:

S60 - This material and its container must be disposed of as hazardous waste
S61 - Avoid release to the environment. Refer to special instructions/safety data sheet

Hazard Symbols:

Xn, N

Storage temperature :

Desiccate at RT

Alternative Distributors of [Nebivolol hydrochloride]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

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