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1-Naphthyl PP1

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Formula: C19H19N5
CAS: 221243-82-9
search Element: naphthyl
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Identification

Structural Formula
1-Naphthyl PP1
CAS:
221243-82-9
EINECS:
Molecular Formula:
C19H19N5
MDL:
MFCD03425471
SMILES:
CC(C)(C)N1C2=C(C(=N1)C3=CC=CC4=CC=CC=C43)C(=NC=N2)N
Synonym:
1-tert-butyl-3-(naphthalen-1-yl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine ; 4-amino-1-tert-butyl-3-(1'-naphthyl)pyrazolo[3,4-d]pyrimidine ; 1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine ; 1h-pyrazolo[3,4-d]pyrimidin-4-amine,1-(1,1-dimethylethyl)-3-(1-naphthalenyl)- ; 1-naphthyl pp1 ; 1-na-pp 1 ; 1-na-pp1


Description

1-Naphthyl PP1 selectively inhibits c-Src family kinases v-Src and Fyn (c-Fyn) as well as c-Abl tyrosine kinase (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, Fyn (c-Fyn), c-Abl, CDK2 and CAMK II respectively). 1-Naphthyl PP1 preferentially inhibits mutant over wild-type kinases (IC50 values are 1.5 vs 1000 nM for I338G v-src and v-src respectively).


Suppliers

Santa Cruz Biotechnology, Inc.
203765
Dayang Chem (Hangzhou) Co.,Ltd.
DC8683472
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CAS equal suppliers

1-NA-PP1
ShangHai Biochempartner Co., Ltd.
BCP09108
1-NA-PP1
Excenen Pharmatech Co., Ltd.
EX-A867
1-NA-PP1
BOC Sciences
BS96288
1-(tert-butyl)-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Hangzhou MolCore BioPharmatech Co.,Ltd.
MC443070
1-(tert-butyl)-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Capot Chemical Co., Ltd.
34057
1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Leap Chem Co., Ltd
LC1368041040
1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Finipharma Ltd
F1064021280

Prices & Availability




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Properties for 1-Naphthyl PP1

Molecular Weight:
317.39 g·mol−1
Density:
1.27 g/cm3
Melting point:
219-222 °C
Boiling point:
527.8 °C at 760 mmHg
Flash point:
273 °C
Solubility:
Soluble in DMSO (~20 mg/ml), chloroform, ethanol (~2 mg/ml), DMF (~30 mg/ml), and 1: 5 solution of DMF: PBS (pH 7.2) (~0.15 mg/ml).
Physical Description:
white cyrstalline solid
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Safety & Transport Information

Storage temperature :
Store at +4 °C
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Alternative Distributors of [1-Naphthyl PP1]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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Downloads

Mol File:
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MSDS:
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