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Naphmethonium dibromide

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Formula: C38H50Br2N4O4
CAS: 505059-27-8

Identification

Structural Formula
Naphmethonium dibromide
CAS:
505059-27-8
EINECS:
Molecular Formula:
C38H50Br2N4O4
MDL:
SMILES:
O=C1c2ccccc2C(=O)N1CCC[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)Cn1c(=O)c2cccc3cccc (c1=O)c23
Synonym:


Description

Naphmethonium dibromide is a very potent allosteric modulator of muscarinic receptors, selective for M2-receptors. Retards the dissociation of the antagonist N-methylscopolamine and exhibits positive cooperativity, i.e. shows higher affinity for occupied receptors compared to free receptors. Naphmethonium dibromide's affinity for the free receptor is about 100-fold higher than with W84. pKA =8.29, p(αKA)=8.66, pEC50,diss=8.36.


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Properties for Naphmethonium dibromide

Molecular Weight:
786.6 g·mol−1
Solubility:
Soluble in DMSO, water or aqueous buffer.
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Safety & Transport Information

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Alternative Distributors of [Naphmethonium dibromide]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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MSDS:
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