Naltrindole Hydrochloride | CAS 111469-81-9

Element: hydrochloride naltrindole

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Identification

Naltrindole Hydrochloride

CAS:

111469-81-9

EINECS:

Molecular Formula:

C₂₆H₂₆ N₂ O₃ . Cl H

MDL:

MFCD00069313

SMILES:

C1CC1CN2CC[C@]34[C@@H]5C6=C(C[C@]3(C2CC7=C4C(=C(C=C7)O)O5)O)C8=CC=CC=C8N6.Cl

Synonym:

naltrindole hydrochloride (nti) non-pept ide delta opi ; 4,8-methanobenzofuro[2,3-a]pyrido[4,3-b]carbazole-1,8a(9h)-diol,7-(cyclopropylmethyl)-5,6,7,8,14,14b-hexahydro-, hydrochloride (1:1),(4bs,8r,8as,14br)- ; naltrindolehcl ; naltrindole hydrochloride ; 4,8-methanobenzofuro[2,3-a]pyrido[4,3-b]carbazole-1,8a(9h)-diol,7-(cyclopropylmethyl)-5,6,7,8,14,14b-hexahydro-, monohydrochloride,(4bs,8r,8as,14br)- (9ci) ; 17-(cyclopropylmethyl)-6,7-dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7-2',3'-indolomorphinan hydrochloride ; 17-(cyclopropylmethyl)-6,7-dehydro-4,5a-epoxy-3,14-dihydroxy-6,7-2',3'-indolomorphinan hydrochloride ; nti hydrochloride ; nti ; naltridole hydrochloride ; 17-(cyclopropylmethyl)-6,7-dehydro-4,5α-epoxy-3,14-dihydroxy-6,7-2',3'-indolomorphinanhydrochloride

Description

Naltrindole Hydrochloride is the hydrochloride salt preparation of Naltrindole, which is an apoptotic agent and an inhibitor of cell growth. Naltrindole has been shown to be a cell permeable, highly potent and selective antagonist of DOR(δ opioids). Mechanistic studies show that Naltrindole treatement reduces phosphorylation of threonine 308 and Akt/PKB on serine 473 in cells. By reducing phosphorylation of Akt/PKB, downstream effectors glycogen synthase kinase-3β and transcription factors such as AFX and FKHR are also reduced.

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DC15506200

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Properties for Naltrindole Hydrochloride

Molecular Weight:

450.96 g·mol−1

Boiling point:

664.2°C at 760 mmHg

Flash point:

355.5°C

Solubility:

methanol: 4.5 mg/mL

Safety & Transport Information

Storage temperature :

-20°C

Alternative Distributors of [Naltrindole Hydrochloride]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.

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