Mithramycin A | CAS 18378-89-7 | Chemical-Suppliers

Element: mithramycin

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C-S » Chemicals » mithramycin-PX74696

Identification

Mithramycin A

CAS:

18378-89-7

EINECS:

Molecular Formula:

C₅₂H₇₆O₂₄

MDL:

MFCD00135618

SMILES:

C[C@@H]1[C@H]([C@@H](C[C@@H](O1)O[C@@H]2C[C@@H](O[C@@H]([C@@H]2O)C)OC3=CC4=CC5=C(C(=O)[C@H]([C@@H](C5)[C@@H](C(=O)[C@H]([C@@H](C)O)O)OC)O[C@H]6C[C@H]([C@@H]([C@H](O6)C)O)O[C@H]7C[C@H]([C@@H]([C@H](O7)C)O)O[C@H]8C[C@]([C@@H]([C@H](O8)C)O)(C)O)C(=C4C(=C3C)O)O)O)O

Synonym:

pa144 ; mithracin ; aurlelicacid ; 2371 ; aurelicacid ; mithramycin ; plicamycin ; a-2371 ; nsc24559 ; mitramycin

Description

Mithramycin A is an antibiotic DNA/RNA polymerase and DNA binding transcriptional inhibitor observed to facilitate TNF-α and Fas-ligand induced apoptosis. As a DNA binding transcriptional inhibitor, mithramycin A binds to GC rich sequences located in the minor groove of DNA and is noted to be reversible and Mg²⁺ dependent. Additionally reported to a block transcriptional activation of the SV40 promoter via competitive binding against Sp1 transcription factor to GC rich areas in the early promoter. Mithramycin A is noted to supress TNF-α induced expression of fractalkine (CX3CL1) mRNA in a dose-dependent manner and to act as an effective differentiation agent of HL60 promyelocytic leukemia cells.

Suppliers

Nantong Xindao Biotech Ltd

NXB6762704

Serva Electrophoresis GmbH

SE6762028

Santa Cruz Biotechnology, Inc.

200909

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Prices & Availability

Data is processed

Properties for Mithramycin A

Molecular Weight:

1085.15 g·mol−1

Density:

1.49 g/cm³

Melting point:

180-183 °C

Boiling point:

1169.84° C at 760 mmHg

Solubility:

Soluble in phosphate buffered saline (1 mg/ml), ethanol, ethyl acetate, lower alcohols, and acetone. Insoluble in water.

Safety & Transport Information

Risk Codes:

R22 - Harmful if swallowed
R26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed

Safety Codes:

S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S38 - In case of insufficient ventilation wear suitable respiratory equipment
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)

Hazard Classes:

6.1(b)

Hazard Symbols:

Xn, T+

Storage temperature :

2-8°C

RID/ADR certification :

3249

Alternative Distributors of [Mithramycin A]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Molekula GmbH | Shanghai Boyle Chemical Co., Ltd. | Cfm Oskar Tropitzsch GmbH | Fermentek Ltd.

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Mol File:

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MSDS:

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