Miltefosine

Mitefosine, a PI 3-kinase and Akt inhibitor belonging to the alkylphosphocholines, has also been shown to inhibit anti-IgE induced histamine release from skin mast cells. Experimental studies show that this agent can reduce cytokines IL-1β, IL-4, and IL-6 in certain skin tissue cells and also strongly impede the esterification of cholesterol. Additionally, Miltefosine displays the ability to methylate CDP-choline and phosphatidylethanolamine which interferes with biosynthesis of phosphatidylcholine. Furthermore, data suggests that this compound can slow down the formation of sphingomyelin, which promotes intracellular accumulation of ceramide. Miltefosine is an inhibitor of CCT and PKC.