Mevastatin (Compactin) | CAS 73573-88-3

Element: mevastatin compactin

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C-S » Chemicals » mevastatin-compactin-PX70230

Identification

Mevastatin (Compactin)

CAS:

73573-88-3

EINECS:

Molecular Formula:

C₂₃H₃₄O₅

MDL:

MFCD05662341

SMILES:

CC[C@H](C)C(=O)O[C@H]1CCC=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O

Synonym:

cs-500 ; ml-236b ; mevastin ; mevastatin ; merastatin ; ml236blactone ; mevastatin(sh) ; compactin ; mevastatin(rg) ; mevastatin api

Description

Mevastatin (Compactin) inhibits HMGCR (HMG-CoA reductase) (K_i for acid form is 1 nM) which in turn inhibits isoprenoid biosynthesis and therefore blocks protein isoprenylation and reduces plasma cholesterol levels in humans. Mevastatin causes cells to arrest early in the G1 phase. Mevastatin is a close structural analog of lovastatin and both agents have the same biochemical and pharmacological activities. Mevastatin is inactive in cell-free assays. In cells however, it is hydrolyzed to the active free acid form by intracellular esterases.

Suppliers

Santa Cruz Biotechnology, Inc.

200853

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Prices & Availability

Data is processed

Properties for Mevastatin (Compactin)

Molecular Weight:

390.51 g·mol−1

Density:

1.13 g/cm³ at 20° C

Melting point:

151-153 °C

Boiling point:

555.01° C at 760 mmHg (Predicted)

Solubility:

DMSO: 20 mg/mL

Safety & Transport Information

Risk Codes:

R26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed

Safety Codes:

S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)

Hazard Symbols:

T+

Storage temperature :

2-8°C

Alternative Distributors of [Mevastatin (Compactin)]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

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