Metyrapone | CAS 54-36-4 | Chemical-Suppliers

Element: metyrapone

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C-S » Chemicals » metyrapone-PX70512

Identification

Metyrapone

CAS:

54-36-4

EINECS:

200-206-2

Molecular Formula:

C₁₄H₁₄N₂O

MDL:

MFCD00006397

SMILES:

CC(C)(C1=CN=CC=C1)C(=O)C2=CN=CC=C2

Synonym:

su-4885 ; su4885 ; metyrapone ; metapirone ; mepyrapone ; metapyrone ; metapyron ; metopiron ; su 4885 ; metyrapon

Description

Metyrapone inhibits the biosynthesis of corticosteroids. Studies report that Metyrapone inhibits the hydroxylase activity of ω/ω-1 from the cytochrome P450-mediated prostaglandin. Has shown to block glucocorticoid synthesis via inhibition of steroid 11-β hydroxylase (CYP11B1). Small concentrations of Metyrapone are reported to rapidly oxidize endogenous NADPH, improve oxidation of cortisol, and inhibit the reduction of cortisone in rat liver studies. Additionally, depletion of luminal NADPH has been observed in the presence of Metyrapone. Inflammatory studies in rats report that Metyrapone regulates the expression of pro-inflammatory cytokines. Metyrapone is an inhibitor of CYP3A4.

Suppliers

CSNpharm, Inc.

CSN11433

Leap Chem Co., Ltd

LC180540

Santa Cruz Biotechnology, Inc.

200597

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Prices & Availability

Data is processed

Properties for Metyrapone

Molecular Weight:

226.27 g·mol−1

Density:

~1.1 g/cm³ (Predicted)

Melting point:

52-55 °C(lit.)

Boiling point:

~384.4° C at 760 mmHg (Predicted)

Flash point:

>230 ºF

Solubility:

Soluble in methanol, dilute mineral acids, water (<2 mg/mL), DMSO (25 mg/mL), and ethanol (25 mg/mL).

Safety & Transport Information

Risk Codes:

R22 - Harmful if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice

Hazard Symbols:

Storage temperature :

Store at +4 °C

Alternative Distributors of [Metyrapone]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Jinan Great Chemical Co., Ltd. | Sino Rarechem Labs Co. Ltd.

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MSDS:

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