1-Methyl-D-tryptophan | CAS 110117-83-4

Element: tryptophan methyl

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C-S » Chemicals » methyl-tryptophan-PX1176946

Identification

1-Methyl-D-tryptophan

CAS:

110117-83-4

EINECS:

Molecular Formula:

C₁₂H₁₄N₂O₂

MDL:

MFCD00274271

SMILES:

CN1C=C(C[C@@H](N)C(O)=O)C2=CC=CC=C12

Synonym:

indoximod ; nlg-8189 ; indoximod (nlg-8189 ) ; 1-methyl-d-tryptophane ; 1-me-d-trp ; (r)-2-amino-3-(1-methyl-1h-indol-3-yl)propanoic acid ; 1-methyl-d-tryptophan 95% ; d-trp(me)-oh ; 1-methyl-d-tryptophan

Description

1-Methyl-D-tryptophan is an inhibitor of the enzymes and indolamine 2,3-dioxygenase 1 (IDO) and indolamine 2,3-dioxygenase 2 (INDOL1), with selectivity for INDOL1. The enzymes perform similar transformations and are responsible for catalyzing the rate-limiting step of oxidative tryptophan catabolism in the kynurenine pathway. IDO activity is correlated with an induction of tolerance and immunosuppresion through activation of regulatory T cells by metabolites generated from tryptophan catabolism. Inhibition of IDO by 1-Methyl-D-tryptophan blocks this induced immune suppression, which has shown utility in suppressing acquired immunities of tumors and indicates potential for chemical intervention of chronic inflammatory diseases.

Suppliers

H&Z Industry Co.,Ltd

HIC4201680

Chemlyte Solutions

CS3781134

Hangzhou Ocean Chemical Co., Ltd.

HOC6932772

Capot Chemical Co., Ltd.

10617

Leap Chem Co., Ltd

LC3781134

Santa Cruz Biotechnology, Inc.

200313

Dayang Chem (Hangzhou) Co.,Ltd.

DC6512604

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CAS equal suppliers

Indoximod

Hangzhou MolCore BioPharmatech Co.,Ltd.

MC34314

Indoximod

ShangHai Biochempartner Co., Ltd.

BCP08015

Indoximod

Excenen Pharmatech Co., Ltd.

EN-3451

Indoximod

CSNpharm, Inc.

CSN15702

D-Trp(Me)-OH

SINO High Goal Chemical Technology Co., Ltd.

SHGCT15849504

D-tryptophan, 1-methyl-

Angene International Limited

AGN-PC-0NXAXM

Prices & Availability

Data is processed

Properties for 1-Methyl-D-tryptophan

Molecular Weight:

218.25 g·mol−1

Density:

1.28

Melting point:

242-245 °C(lit.)

Boiling point:

429.30° C at 760 mmHg (Predicted)

Solubility:

Soluble in water (slightly), and acetic acid.

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Alternative Distributors of [1-Methyl-D-tryptophan]

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