6-Methoxy-2-Naphthylacetic acid | CAS 23981-47-7

Element: naphthylacetic methoxy acid

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C-S » Chemicals » methoxy-naphthylacetic-acid-PX77331

Identification

6-Methoxy-2-Naphthylacetic acid

CAS:

23981-47-7

EINECS:

245-967-1

Molecular Formula:

C₁₃H₁₂ O₃

MDL:

MFCD00033105

SMILES:

COC1=CC2=C(C=C1)C=C(C=C2)CC(=O)O

Synonym:

2-naphthaleneaceticacid, 6-methoxy- ; desmethyl naproxen ; desmethyl naproxe ; brl 10720 ; 6-methoxy-2-naphthylacetic acid ; 6-methoxy naphthalene acetic acid ; 6-methoxy-2-naphthaleneacetic acid ; brl10720 ; 6-mna ; 6-metossi-2-naphtilacetico ; 6-methoxynaphthalene-2-acetic acid ; 2-(6-methoxy-2-naphthyl)aceticacid ; 6-methoxy-2-naphthaleneaceticaci ; 2-(6-methoxy-2-naphthyl)acetic acid

Description

6-Methoxy-2-Naphthylacetic acid is a competitive inhibitor of Cox (cyclooxygenase). 6-Methoxy-2-Naphthylacetic acid is selective for Cox-2 (IC₅₀ = 15-55 μM) over Cox-1 (IC₅₀ = 200-280 μM). 6-Methoxy-2-Naphthylacetic acid is a metabolite of Nabumetone with potential analgesic and anti-inflammatory effects. 6-Methoxy-2-Naphthylacetic acid has been shown to alter the pharmacokinetics and brain accumulation of IMP in monkeys. 6-Methoxy-2-Naphthylacetic acid was able to decrease reactive oxygen species creation in polymorphonuclear leukocytes. Evidence points out that 6-Methoxy-2-Naphthylacetic acid is phototoxic in vitro.

Suppliers

Chemlyte Solutions

CS16745022

DSL Chemicals (Shanghai) Co., Ltd.

DC316212648

Santa Cruz Biotechnology, Inc.

200602

Dayang Chem (Hangzhou) Co.,Ltd.

DC288311532

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CAS equal suppliers

Naproxen EP Impurity I

Aozeal Certified Standards (AOCS), Inc.

N0006.11

6-Methoxy-2-Naphthaleneacetic Acid

DSL Chemicals (Shanghai) Co., Ltd.

C041487

6-Methoxy-2-Naphthaleneacetic Acid

Leap Chem Co., Ltd

LC18365508

6-Methoxy-2-Naphthaleneacetic Acid

Finipharma Ltd

F14282856

6-Methoxy-2-naphthaleneacetic Acid

Pharmaffiliates Analytics & Synthetics Pvt. Limited

PA 14 13090

2-Naphthaleneacetic acid, 6-methoxy-

Angene International Limited

AGN-PC-07A22I

(6-Methoxy-naphthalen-2-yl)-acetic acid

Manchester Organics Limited

P19741

2-(6-Methoxynaphthalen-2-yl)acetic acid

Ambeed, Inc.

A326956

2-(6-Methoxynaphthalen-2-yl)acetic acid

BLD Pharmatech Ltd

BP351010530

Prices & Availability

Data is processed

Properties for 6-Methoxy-2-Naphthylacetic acid

Molecular Weight:

216.2326 g·mol−1

Density:

1.235 g/cm3

Melting point:

171-173°C

Boiling point:

408.8 °C at 760 mmHg

Flash point:

160.7 °C

Solubility:

Soluble in DMSO (25 mg/mL) and ethanol (10 mg/mL warm)

Physical Description:

off-white solid

Safety & Transport Information

Risk Codes:

R22 - Harmful if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
R37/38 - Irritating to respiratory system and skin
R41 - Risk of serious damage to eyes
R50 - Very toxic to aquatic organisms

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S39 - Wear eye/face protection
S61 - Avoid release to the environment. Refer to special instructions/safety data sheet

Hazard Symbols:

Xn, Xi, N

Storage temperature :

Refrigerator

Alternative Distributors of [6-Methoxy-2-Naphthylacetic acid]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Synfine Research Inc. | Annker Organics Co., Ltd. | Jinan Haohua Industry Co., Ltd. | Gihi Chemicals Co., Limited | Clearsynth Canada INC.

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