Methotrexate | CAS 133073-73-1 | Chemical-Suppliers

Element: methotrexate

Page Content Identification Properties Suppliers Prices & Availability Get Quick Quote ☰

Identification Properties Suppliers Prices & Availability Get Quick Quote

C-S » Chemicals » methotrexate-PX66678

Identification

Methotrexate

CAS:

133073-73-1

EINECS:

Molecular Formula:

C₂₀H₂₂N₈O₅

MDL:

MFCD00150847

SMILES:

CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O

Synonym:

l-(+)-amethopterin hydrate ; l-amethopterin hydrate ; (+)-amethopterin hydrate ; l-mtx ; methylaminopterin hydrate ; antifolan hydrate ; methotrexate hydrate ; (+)amethopterine hydrate ; mtx hydrate ; methotrexate trihydrate

Description

Methotrexate is a cell cycle arresting agent with varying effects. Methotrexate arrests the cell cycle in late G₁/S-phase, therefore inhibiting the synthesis of DNA, RNA, thymidylates, and proteins. In the previous cases the inhibition of enzymes involved in purine metabolism, leading to accumulation of adenosine, or the suppression of intercellular adhesion molecule expression by T cells as the main mechanism of action by methotrexate. The compound has been observed to irreversibly inhibit dihydrofolate reductase (DHFR) and thymidylate synthetase (TS). Methotrexate has been shown to modulate inflammation by promoting adenosine release or inhibiting transmethylation reactions. In adherent splenic cells, IL-1 production was decreased by methorexate.
Additionally offered as methotrexate trihydrate.

Suppliers

Ambeed, Inc.

A103612

Shandong Ench Chemical Co.,Ltd

SECC3601800

Biovectra Dcl

BD156468

Indofine Chemical Co, Inc.

Bio-261

EXCELLA GmbH

E144288

Alfa (A Johnson Matthey Company)

A3841152

Sancai Industry Co.,Ltd.

SIC2881152

Hainan Zhongxin Chemical Co., Ltd.

HZC4081632

CSNpharm, Inc.

CSN16844

Sigma-Aldrich International GmbH

SI3841152

Leap Chem Co., Ltd

LC216648

Santa Cruz Biotechnology, Inc.

3507

Get Quick Quote

CAS equal suppliers

Methotrexate hydrate

Santa Cruz Biotechnology, Inc.

SCB12004800

Methotrexate hydrate

AK Scientific, Inc.

AS7602280

Methotrexate hydrate

ShangHai Biochempartner Co., Ltd.

BCP13701

Methotrexate hydrate

Excenen Pharmatech Co., Ltd.

EN-3648

L-Amethopterinhydrate

Huateng Pharmaceutical Co.,Ltd

814477

Methotrexate dihydrate

Chemieliva Pharmaceutical Co., Ltd.

CP15404620

Methotrexate dihydrate

Haihang Industry Co., Ltd.

HI11443432

Methotrexate trihydrate

Santa Cruz Biotechnology, Inc.

215309

L(+)-Amethopterin Hydrate

Hangzhou J&H Chemical Co., Ltd.

HJC23259300

L(+)-Amethopterin Hydrate

Haihang Industry Co., Ltd.

HI19505850

L(+)-Amethopterin hydrate

Dayang Chem (Hangzhou) Co.,Ltd.

DC23259300

L(+)-Amethopterin hydrate

Gihi Chemicals Co., Limited

GCL20258100

L(+)-Amethopterin hydrate

Chemlyte Solutions

CS13504050

L(+)-Amethopterin hydrate, 99%

Acros Organics BVBA

AOB17106840

(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid hydrate(1:x)

BLD Pharmatech Ltd

BP1762252866

(2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid

Xingrui Industry Co., Limited

XIL35438141752

Prices & Availability

Data is processed

Properties for Methotrexate

Molecular Weight:

454.44 g·mol−1

Melting point:

195 °C

Solubility:

H₂O: insoluble

Physical Description:

yellow to orange crystalline powder

Safety & Transport Information

Risk Codes:

R25 - Toxic if swallowed
R36/38 - Irritating to eyes and skin
R46 - May cause inheritable genetic damage
R61 - May cause harm to the unborn child

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
S36/37 - Wear suitable protective clothing and gloves
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
S53 - Avoid exposure - obtain special instructions before use

Hazard Symbols:

Storage temperature :

-20°C

RID/ADR certification :

UN 2811 6.1 / PG 3

Alternative Distributors of [Methotrexate]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified