kisspeptin-14 (5-14) (human) ; 16: pn: wo2007072997 seqid: 16claimed protein ; metastin (45-54), human ; human metastin 45-54 ; metastin (human, 45-54) ; metastin (45-54) ; 16:pn: wo2004063221 seqid: 16 claimed protein ; human kiss-10f ; kisspeptin-10 ; kisspeptin-10 (human) ; h-ynwnsfglrf-nh2 ; 6: pn: wo03027149 seqid: 6 claimed protein ; kisspeptin-13 (4-13) (human) ; l-phenylalaninamide,l-tyrosyl-l-asparaginyl-l-tryptophyl-l-asparaginyl-l-seryl-l-phenylalanylglycyl-l-leucyl-l-arginyl- ; human kisspeptin 10f ; kiss-1 (112-121) (human) ; kiss-1 (112-121) ; kiss-1
Description
Metastin (45-54) is a decapeptide with C-terminally amidated LRF-motif which acts as a potent and selective agonist of AXOR12 (GPR54, a novel human G-protein-coupled receptor). Metastin (45-54) induces an increase in intracellular Ca2+ levels in CHO/h175 and CHO/AXOR12:Gqi5 cells and exhibits about 8-fold higher receptor binding affinity (Ki = 42 pM) compared to Metastin.