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Mepyramine maleate

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Formula: C17H23N3O.C4H4O4
CAS: 59-33-6
search Element: mepyramine maleate
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Identification

Structural Formula
Mepyramine maleate
CAS:
59-33-6
EINECS:
200-422-7
Molecular Formula:
C17H23N3O.C4H4O4
MDL:
MFCD00069333
SMILES:
CN(C)CCN(CC1=CC=C(C=C1)OC)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O
Synonym:
pymafed ; histatex ; bimaleate ; stangenmaleate ; minihist ; antihist ; pyramaleate ; renstamin ; pyraninyl ; paramal


Description

Mepyramine maleate is a histamine H1 receptor antagonist and binds with high affinity to G(q/11) protein. Mepyramine maleate is found to be a potent inhibitor of CYP2D6 (P450 2D forms) in hepatocytes, and PAF-induced platelet aggregation. Mepyramine maleate is commonly utilized as a radioligand ([3H]Mepyramine) binding assay for the H1 receptor. This product has been recently discovered to exhibit blocking ability of KCNQ/M channels which is potentially related to an adverse effect seen in excess intake of antihistamines.


Suppliers

Krada CPS Industry S.L
KCIS7923960
+
CSNpharm, Inc.
CSN11809
Sigma-Aldrich International GmbH
SI11523456
+
Leap Chem Co., Ltd
LC6481944
+
Santa Cruz Biotechnology, Inc.
203629
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Prices & Availability




Data is processed


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Properties for Mepyramine maleate

Molecular Weight:
401.46 g·mol−1
Melting point:
101-103 °C
Boiling point:
423.8° C at 760 mmHg (Predicted)
Solubility:
Soluble in water (100 mg/ml), methanol, Phosphate buffered saline (100 mM), alcohol (1: 2.5 - 3.0), and chloroform (1: 2).
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Safety & Transport Information

Risk Codes:
R22 - Harmful if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37 - Wear suitable protective clothing and gloves
Hazard Symbols:
Xn
Hazard symbol Xn
Storage temperature :
2-8°C
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Alternative Distributors of [Mepyramine maleate]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Nantong Chem-Tech. (Group) Co., Ltd. | Jinan Great Chemical Co., Ltd. | Clearsynth Canada INC.

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