(S)-Mephenytoin | CAS 70989-04-7

Element: mephenytoin

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C-S » Chemicals » mephenytoin-PX72174

Identification

(S)-Mephenytoin

CAS:

70989-04-7

EINECS:

Molecular Formula:

C₁₂H₁₄ N₂ O₂

MDL:

MFCD00270025

SMILES:

CC[C@@]1(C(=O)N(C(=O)N1)C)C2=CC=CC=C2

Synonym:

(s)-(+)-mephenytoin ; (+)-5-ethyl-3-methyl-5-phenylhydantoin ; (s)-mephenytoine ; (s)-5-ethyl-3-methyl-5-phenylhydantoin ; (+)-mesantoin ; (s)-(+)-5-ethyl-3-methyl-5-phenylhydantoin ; (5s)-5β-ethyl-3-methyl-5-phenylhydantoin ; (+)-mephenytoin ; 2,4-imidazolidinedione,5-ethyl-3-methyl-5-phenyl-, (s)- ; d-mephenytoin ; mephenitoin s ; (s)-mephenytoin ; (5s)-5-ethyl-3-methyl-5-phenylhydantoin ; (5s)-5-ethyl-3-methyl-5-phenylimidazolidine-2,4-dione ; (+)-s-mephenytoin ; 2,4-imidazolidinedione,5-ethyl-3-methyl-5-phenyl-, (5s)- ; (s)-5-ethyl-3-methyl-5-phenylimidazolidine-2,4-dione

Description

(S)-Mephenytoin is a hydantoin small molecule, originally discovered and implemented for its anticonvulsant effects. Individuals present a variable ability to perform hydroxylation of (S)-Mephenytoin at the 4'-position associated with polymorphism in CYP2C19, an oxidase in the cytochrome P-450 system. The poor metabolizer phenotype, those incapable of metabolizing (S)-Mephenytoin by 4'-hydroxylation, also show a reduced ability to clear other pharmaceuticals and xenobiotics, and this (S)-Mephenytoin metabolism experiment has been used to explore the implications of this common phenotypic condition in drug design and toxicity expectations. (S)-Mephenytoin is a substrate of CYP2B6 and CYP2C19.

Suppliers

Amadis Chemical Company Limited

ACCL9304650

Santa Cruz Biotechnology, Inc.

200975

Dayang Chem (Hangzhou) Co.,Ltd.

DC9303720

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CAS equal suppliers

(S)-Mephenytoin ((S)-5-Ethyl-3-methyl-5-phenylhydantoin)

United States Biological

M2915

Prices & Availability

Data is processed

Properties for (S)-Mephenytoin

Molecular Weight:

218.25 g·mol−1

Density:

1.16 g/cm³ (Predicted)

Melting point:

135-138 °C

Solubility:

Soluble in ethanol (50 mg/ml), DMSO (50 mg/ml), acetone, chloroform, and Ethyl Acetate.

Safety & Transport Information

Risk Codes:

R22 - Harmful if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing

Hazard Symbols:

Storage temperature :

2-8°C

Alternative Distributors of [(S)-Mephenytoin]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Spectrum Chemical Mfg. Corp.