MEG (sulfate) | CAS 3979-00-8 | Chemical-Suppliers

Element: sulfate

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C-S » Chemicals » meg-sulfate-PX78515

Identification

MEG (sulfate)

CAS:

3979-00-8

EINECS:

Molecular Formula:

C₃H₁₁N₃O₄S₂

MDL:

MFCD03789572

SMILES:

C(CS)N=C(N)N.C(CS)N=C(N)N.OS(=O)(=O)O

Synonym:

MEG SULFATE ; meg hemisulfate salt ; mercaptoethylguanidine hemisulfate salt ; ; (2-MERCAPTOETHYL)-GUANIDINE SULFATE

Description

MEG (sulfate) is a selective scavenger of peroxynitrite and a NOS2 (iNOS) inhibitor. The EC₅₀ values for inhibition of NOS2 (LPS-treated rat lung), NOS3 (eNOS) (bovine endothelial), and NOS1 (nNOS) (rat brain) are 11.5, 110, and 60 μM, respectively. MEG reacts with peroxynitrite with a second order rate constant of 1,900 M^-1s^-1 at 37°C. MEG (sulfate) also has potent anti-inflammatory activity, which may be due to the combined effect of MEG acting as an inhibitor of NOS2 and as a scavenger of peroxynitrite.