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MeBIO

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Formula: C17H12BrN3O2
CAS: 667463-95-8
search Element: mebio
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Identification

Structural Formula
MeBIO
CAS:
667463-95-8
EINECS:
Molecular Formula:
C17H12BrN3O2
MDL:
SMILES:
CN1C2=C(C=CC(=C2)Br)/C(=C/3C(=C4C=CC=CC4=N3)NO)/C1=O
Synonym:
1-methyl-bio ; mebio ; 2h-indol-2-one, 6-bromo-3-[(3e)-1,3-dihydro-3-(hydroxyimino)-2h-indol-2-ylidene]-1,3- dihydro-1-methyl-, (3z)- ; (2'z,3'e)-6-bromo-1-methylindirubin-3'-oxime ; gsk-3 inhibitor xiv, control


Description

MeBIO is an analog of 6-bromoindirubin-3'-oxime (BIO), which acts as an aryl hydrocarbon receptor (AhR) agonist. MeBIO inhibits the phosphorylation of Tyr276/216, the active site on the enzyme GSK-3α/β, which suppresses the activity of the ezyme. GSK-3 is a serine/threonine protein kinase which inactivates glycogen synthase and mediates the phosphorylation of specific amino acids that contain serine and threonine. Studies indicate that MeBIO and other indirubins are beneficial tools, along with lithium and kenpaullone to study the cellular functions of GSK-3. MeBIO acts as a weak antagonist against CDK1/Cyclin B and CDK5/p25 activity.


Suppliers

Santa Cruz Biotechnology, Inc.
357370
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Prices & Availability




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Properties for MeBIO

Molecular Weight:
370.20 g·mol−1
Solubility:
Soluble in DMSO (100 mM), and ethanol (10 mM).
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Safety & Transport Information

Storage temperature :
Store at +4 °C
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Alternative Distributors of [MeBIO]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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Downloads

Mol File:
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MSDS:
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