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Margatoxin, Recombinant

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Formula: C178H286 N52 O50 S7
CAS: 145808-47-5

Identification

Structural Formula
Margatoxin, Recombinant
CAS:
145808-47-5
EINECS:
Molecular Formula:
C178H286 N52 O50 S7
MDL:
MFCD00132225
Synonym:
margatoxin ; margatoxin (9ci) ; margatoxin (scorpion) ; 34),(17® ; 27: pn:wo2008088422 figure: 7a claimed protein ; rmargatoxin ; margatoxin, recombinant ; 36)-tris(disulfide) ; margatoxin (mgtx) ; mgtx (scorpion) ; l-histidine,l-threonyl-l-isoleucyl-l-isoleucyl-l-asparaginyl-l-valyl-l-lysyl-l-cysteinyl-l-threonyl-l-seryl-l-prolyl-l-lysyl-l-glutaminyl-l-cysteinyl-l-leucyl-l-prolyl-l-prolyl-l-cysteinyl-l-lysyl-l-alanyl-l-glutaminyl-l-phenylalanylglycyl-l-glutaminyl-l-seryl-l-alanylglycyl-l-alanyl-l-lysyl-l-cysteinyl-l-methionyl-l-asparaginylglycyl-l-lysyl-l-cysteinyl-l-lysyl-l-cysteinyl-l-tyrosyl-l-prolyl-,cyclic (7® ; rmgtx ; scorpion venom centruroides sculpturatus ; 29),(13® ; mgtx ; bark scorpion venom


Description

Margatoxin, Recombinant is originally isolated from the scorpion Centruroides margaritatus, is a specific blocker of Kv1.3, Kv1.6 channels and a splice variant of the Drosophila Shaker channels. In Xenopus oocytes the toxin was less potent and inhibited expressed Kv1.3 channels with an apparent IC50 of ~1 nM. Margatoxin has been shown induce c-fos like protein and mRNA in rat organotypic dorsal striatal slices. But in human endothelial cells margatoxin inhibited VEGF-induced hyperpolarization, proliferation and nitric oxide production.


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Santa Cruz Biotechnology, Inc.
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Properties for Margatoxin, Recombinant

Molecular Weight:
4178.95 g·mol−1
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Safety & Transport Information

Safety Codes:
S22 - Do not breathe dust
Storage temperature :
-20°C
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Alternative Distributors of [Margatoxin, Recombinant]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Chem-Impex International, Inc. | Shanghai Hanhong Chemical Co., Ltd. | Rif Life Science Co., Limited

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MSDS:
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