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4-(N-Maleimidomethyl)cyclohexane-1-carboxylic acid 3-sulfo-N-hydroxysuccinimide ester sodium salt (cis/trans mixture)

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Formula: C16H18N2O9S.Na
CAS: 92921-24-9
search Element: hydroxysuccinimide maleimidomethyl cyclohexane carboxylic mixture sodium ester sulfo trans acid salt
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Identification

Structural Formula
4-(N-Maleimidomethyl)cyclohexane-1-carboxylic acid 3-sulfo-N-hydroxysuccinimide ester sodium salt (cis/trans mixture)
CAS:
92921-24-9
EINECS:
Molecular Formula:
C16H18N2O9S.Na
MDL:
MFCD00054978
Synonym:
3-pyrrolidinesulfonicacid,1-[[[4-[(2,5-dihydro-2,5-dioxo-1h-pyrrol-1-yl)methyl]cyclohexyl]carbonyl]oxy]-2,5-dioxo-,sodium salt (9ci) ; smcc, water-soluble ; 4-[(2,5-dihydro-2,5-dioxo-1h-pyrrol-1-yl)methyl]-cyclohexanecarboxylic acid 2,5-dioxo-3-sulfo-1-pyrrolidinyl ester sodium salt (1:1) ; sulfo-smcc crosslinker ; sulfo-smcc sodium ; sulfo-smcc ; sulfo succinimidyl-4-(n-maleimido methyl) cyclohexane-1-carboxylate ; sulfo-n-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate ; 4-(n-maleimidomethyl)cyclohexane-1-*carboxylic ac ; sulfo-smccsulfosuccinimidyl-trans-4-(n-maleimidomethyl) ; sulpho smcc sodium salt ; sulfo-smcc sodium salt


Description

A heterobifunctional cross-linking reagent with amine and thiol reactivity. Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. Contains 9 atom linker. An extended aliphatic spacer stabilizes the maleimide prior to coupling compared to aromatic spacers. It is an alternative to normal SMCC (MAA1000) equipped with enhanced water solubility through the additional sulfonic acid moiety. This reagent couples to molecules containing primary amine by amide bond formation in buffered solution at pH 7.5 (6.5-8.5). The second coupling to thiol containing molecules by forming thioether linkage is carried out at pH 6.8 (6.5-7.0).


Suppliers

Iris Biotech GmbH
MAA1050
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Cyclohexanecarboxylicacid, 4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-,2,5-dioxo-3-sulfo-1-pyrrolidinyl ester, sodium salt (1:1)
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Prices & Availability




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Properties for 4-(N-Maleimidomethyl)cyclohexane-1-carboxylic acid 3-sulfo-N-hydroxysuccinimide ester sodium salt (cis/trans mixture)

Molecular Weight:
436.37 g·mol−1
Melting point:
>270 °C (dec.)
Physical Description:
solid
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Hazard Statements

GHS07

GHS03
Harmful
  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    - Respiratory tract irritation
    - Narcotic effects
    • Not used
  • with the "skull and crossbones" pictogram
  • for skin or eye irritation if:
  • the "corrosion" pictogram also appears
  • the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:
R36/37/38 - Irritating to eyes, respiratory system and skin
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
Hazard Symbols:
Xi
Hazard symbol Xi
Storage temperature :
0-6°C
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Alternative Distributors of [4-(N-Maleimidomethyl)cyclohexane-1-carboxylic acid 3-sulfo-N-hydroxysuccinimide ester sodium salt (cis/trans mixture)]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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