Loperamide Hydrochloride | CAS 34552-83-5

Element: hydrochloride loperamide

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C-S » Chemicals » loperamide-hydrochloride-PX70044

Identification

Loperamide Hydrochloride

CAS:

34552-83-5

EINECS:

252-082-4

Molecular Formula:

C₂₉H₃₃ClN₂O₂.HCl

MDL:

MFCD00058581

SMILES:

CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4.Cl

Synonym:

pj185 ; r18553 ; clalet ; blox ; lopemin ; loperyl ; imosec ; imodium ; imosse ; lopemid

Description

Loperamide Hydrochloride is an opiate agonist with selectivity for the MOR (μ-opiod receptor). This specificity for μ-opioid receptors and limited penetrability into the brain prevent Loperamide from demonstrating central systemic effects generally associated with opiates, instead demonstrating localized action on the nociceptor and resultant antihyperalgesic action. Loperamide is shown to have an effect on the Ca²⁺ flux through high-voltage-activated calcium channels in response to high levels of extracellular K⁺, and at higher concentrations Loperamide is also a calcium channel protein inhibitor via the N-methyl-D-aspartate (NMDA) receptor-operated ion channel.

Suppliers

Ambeed, Inc.

A171923

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI331213248

Shandong SanYoung Industry Co., Ltd

SSI16806720

Chemlyte Solutions

CS8642592

Sigma-Aldrich International GmbH

SI15364608

Finetech Industry Limited

FIL12004800

Hefei Hirisun Pharmatech Co., Ltd

HR013711

CM Fine Chemicals

CFC8163264

AK Scientific, Inc.

AS9122736

Xingrui Industry Co., Limited

XIL13925568

Amadis Chemical Company Limited

ACCL14887440

Leap Chem Co., Ltd

LC8642592

Santa Cruz Biotechnology, Inc.

203116

Dayang Chem (Hangzhou) Co.,Ltd.

DC14885952

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CAS equal suppliers

Loperamide HCl

CSNpharm, Inc.

CSN11328

Loperamide hydrochloride, 98+%

Alfa (A Johnson Matthey Company)

A19205760

Usp loperamide hydrochloride api

Gihi Chemicals Co., Limited

GCL345613824

Prices & Availability

Data is processed

Properties for Loperamide Hydrochloride

Molecular Weight:

513.5 g·mol−1

Melting point:

223-225 °C

Solubility:

Soluble in water (160 mg/ml), methanol (286 mg/ml), ethanol (53.7 mg/ml), DMSO (205 mg/ml), and chloroform.

Safety & Transport Information

Risk Codes:

R25 - Toxic if swallowed

Safety Codes:

S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)

Hazard Classes:

6.1(b)

Hazard Symbols:

Storage temperature :

Store at RT

RID/ADR certification :

UN 2811 6.1 / PG 3

Alternative Distributors of [Loperamide Hydrochloride]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

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