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Lipase Inhibitor, THL

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Formula: C29H53NO5
CAS: 96829-58-2
search Element: inhibitor lipase

Identification

Structural Formula
Lipase Inhibitor, THL
CAS:
96829-58-2
EINECS:
Molecular Formula:
C29H53NO5
MDL:
MFCD05662360
SMILES:
CCCCCCCCCCC[C@@H](C[C@H]1[C@@H](C(=O)O1)CCCCCC)OC(=O)[C@H](CC(C)C)NC=O
Synonym:
ro-18-0647 ; orlistat ; oristat ; orlipastatum ; orlistate ; xenical ; orlipastat ; ro 18-0647/002 ; orlistat powder ; olistat


Description

Lipase Inhibitor, THL (Tetrahydrolipstatin), is a compound that has been shown to rapidly inactivate lipoprotein lipase (LPL). This agent has been found to bind both subunits of LPL, induce tetramerisation, and cause local conformational changes. The exception to lipase inhibition capacities of THL is phospholipase A2, which is not affected by THL. Mechanistic studies suggest that THL inhibits the thioesterase domain of fatty acid synthase (FAS) and as a result halts cell proliferation and causes cell apoptosis. More detailed experiments show that gradually THL affects the retinoblastoma protein pathway and leads to cell-cycle arrest at G1/S boundary. Lipase Inhibitor, THL is an inhibitor of pancreatic and gastric lipase, as well as carboxyl ester lipase (CEL) and diacylglycerol lipase-α (DAGLα). Lipase Inhibitor, THL also activates caspase-3.


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Santa Cruz Biotechnology, Inc.
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Properties for Lipase Inhibitor, THL

Molecular Weight:
495.73 g·mol−1
Melting point:
<50 °C
Boiling point:
615.88° C at 760 mmHg (Predicted)
Solubility:
DMSO: 19 mg/mL
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Safety & Transport Information

Storage temperature :
2-8°C
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Alternative Distributors of [Lipase Inhibitor, THL]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Haihang Industry Co., Ltd.

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