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Linoleoyl Ethanolamide-d4

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Formula: C20H37 N O2
CAS: 68171-52-8

Identification

Structural Formula
Linoleoyl Ethanolamide-d4
CAS:
68171-52-8
EINECS:
Molecular Formula:
C20H37 N O2
MDL:
MFCD00674434
Synonym:
linoleamide, n-(2-hydroxyethyl)- (7ci) ; anandamide ; n-(2-hydroxyethyl)linoleamide ; lea ; anandamide (18:2,n6) ; linoleic ethanolamine ; n-linoleoylethanolamine ; linoleoyl monoethanolamide ; n-(2-hydroxyethyl)-(z,z)-9,12-octadecadienamide ; odnhetoh ; linoleoylethanolamide ; linoleicacid monoethanolamide ; linoleylethanolamide ; 9,12-octadecadienamide,n-(2-hydroxyethyl)-, (9z,12z)- ; einecs 269-029-6 ; linoleic ethanolamide ; 9,12-octadecadienamide,n-(2-hydroxyethyl)-, (z,z)-


Description

Linoleoyl ethanolamide is an endocannabinoid detected in porcine brain and murine peritoneal macrophages which contains linoleate in place of the arachidonate moiety of arachidonoyl ethanolamide (AEA). It has weak affinity for the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors, exhibiting Ki values of 10 µM and 25 µM, respectively. However, it is only approximately 4-fold less potent than AEA at causing catalepsy in mice (ED50 of 26. mg/kg). In addition, linoleoyl ethanolamide increases ERK phosphorylation and AP-1-dependent transcription approximately 1.-fold at 15 µM in a CB-receptor-independent manner. However, cellular toxicity is readily apparent at concentrations of 10-20 µM. Linoleoyl ethanolamide inhibits human fatty acid amide hydrolase-dependent hydrolysis of AEA with a Ki value of 9.0 µM, but also is hydrolyzed effectively by the enzyme.


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Properties for Linoleoyl Ethanolamide-d4

Molecular Weight:
323.5133 g·mol−1
Density:
0.926 g/cm3
Boiling point:
499.1 °C at 760 mmHg
Flash point:
255.6 °C
Physical Description:
ethanol solution
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Safety & Transport Information

Risk Codes:
R11 - Highly flammable
R36/37/38 - Irritating to eyes, respiratory system and skin
Safety Codes:
S16 - Keep away from sources of ignition - No smoking
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
Hazard Symbols:
F, Xi
Hazard symbol F Hazard symbol Xi
Storage temperature :
-20°C
RID/ADR certification :
UN 1170 3 / PG 2
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Alternative Distributors of [Linoleoyl Ethanolamide-d4]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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MSDS:
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