Leflunomide | CAS 75706-12-6 | Chemical-Suppliers

Element: leflunomide

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C-S » Chemicals » leflunomide-PX76883

Identification

Leflunomide

CAS:

75706-12-6

EINECS:

Molecular Formula:

C₁₂H₉F₃N₂O₂

MDL:

MFCD00867593

SMILES:

CC1=C(C=NO1)C(=O)NC2=CC=C(C=C2)C(F)(F)F

Synonym:

leflunomideusp31 ; isoxazol lefunomide ; rs-34821 ; leflunamide ; leflunomide, >=99% ; leflunomida ; leflunomide ; hwa 486 ; arava ; leflunomide (200 mg)

Description

Leflunomide is an immunosuppressive drug that inhibits T and B cell responses. Leflunomide is an inhibitor of Cox-2, of tyrosine phosphorylation (tyrosine kinase), of DHODH (dihydroorotate dehydrogenase), an enzyme for de novo pyrimidine synthesis, and of TNF-dependent NF-κB activation. The physiological activity of leflunomide is attributed mainly to its metabolite A77 1726.

Suppliers

H&Z Industry Co.,Ltd

HIC220880

Aea.ltd

A77154

Shandong SanYoung Industry Co., Ltd

SSI3851540

XD BIOCHEMS Ltd

XB165495

Ambeed, Inc.

A133761

Chemlyte Solutions

CS198594

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI7593036

Cangzhou Goldlion Chemicals Co., Ltd.

CGC4071628

Austin Chemical Company, Inc.

ACC3191276

Alfa (A Johnson Matthey Company)

A3521056

Hangzhou Verychem Science & Technology Co., Ltd.

HVST5282640

Xiamen Equation Chemical Co.,Ltd

XECC3521760

CSNpharm, Inc.

CSN16462

Sigma-Aldrich International GmbH

SI3521056

scienTEST - bioKEMIX GmbH

S-B2751100

Finetech Industry Limited

FIL2751100

Carbone Scientific Co., Ltd.

CS308924

CM Fine Chemicals

CFC187748

AK Scientific, Inc.

AS209627

Xingrui Industry Co., Limited

XIL3191276

Amadis Chemical Company Limited

ACCL3411705

Leap Chem Co., Ltd

LC198594

Santa Cruz Biotechnology, Inc.

202209

Dayang Chem (Hangzhou) Co.,Ltd.

DC3411364

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CAS equal suppliers

Leflunomida

Arakato Development Ltd

AD253759

Leflunomida

Nantong Xindao Biotech Ltd

NXB2861144

5-methylisoxazole-4-(4-trifluoromethyl)carboxanilide

Hangzhou J&H Chemical Co., Ltd.

HJC644825792

4-Isoxazolecarboxamide, 5-methyl-n-[4-(trifluoromethyl)phenyl]-

Angene International Limited

AGN-PC-07A21Q

5-Methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide

BLD Pharmatech Ltd

BP806424192

Prices & Availability

Data is processed

Properties for Leflunomide

Molecular Weight:

270.21 g·mol−1

Density:

1.39 g/cm³ (Predicted)

Melting point:

163-168 °C

Boiling point:

289.31° C at 760 mmHg (Predicted)

Solubility:

Soluble in DMSO (54 mg/ml at 25° C), ethanol (54 mg/ml at 25° C), and water (<1 mg/ml at 25° C).

Hazard Statements

GHS06
Toxic

Acute toxicity (oral, dermal, inhalation), categories 1, 2, 3

Safety & Transport Information

Risk Codes:

R22 - Harmful if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing

Hazard Symbols:

Xn, Xi

Storage temperature :

2-8°C

RID/ADR certification :

UN 2811 6.1 / PG 3

Alternative Distributors of [Leflunomide]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified