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Kifunensine

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Formula: C8H12 N2 O6
CAS: 109944-15-2
search Element: kifunensine
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Identification

Structural Formula
Kifunensine
CAS:
109944-15-2
EINECS:
Molecular Formula:
C8H12 N2 O6
MDL:
SMILES:
C([C@@H]1[C@H]([C@@H]([C@@H]([C@@H]2N1C(=O)C(=O)N2)O)O)O)O
Synonym:
kifunensine ; imidazo1,2-apyridine-2,3-dione, hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-, (5r,6r,7s,8r,8as)- ; fr 900494 ; kifunensine min. 99% ; (+)-kifunensine ; fr 900494, hexahydro-6r,7s,8as-trihydroxy-5r-(hydroxymethyl)-imidazo[1,2-a] pyridine-2,3-dione ; (5r,8as)-1,5,6,7,8,8a-hexahydro-6β,7α,8α-trihydroxy-5α-(hydroxymethyl)imidazo[1,2-a]pyridine-2,3-dione ; hexahydro-6r,7s,8as-trihydroxy-5r-(hydroxymethyl)-imidazo[1,2-a] pyridine-2,3-dione ; imidazo[1,2-a]pyridine-2,3-dione,hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-, [5r-(5a,6b,7a,8a,8aa)]- ; [5r-(5α,6β,7α,8α,8aα)]- ; kifunensine, kitasatosporia kifunense ; imidazo[1,2-a]pyridine-2,3-dione,hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-, (5r,6r,7s,8r,8as)- ; (5r,6r,7s,8r,8as)-hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione


Description

Kifunensine is an immunoactive compound originally produced by Kitasatosporia kifunense, which displays competitive inhibition against immunosuppressive factor in tumor-bearing mice. Kifunensine has also been shown to be a potent inhibitor of the purified glycoprotein processing enzyme, mannosidase I (MAN1), specifically MAN1A1, MAN1A2, MAN1B1 and MAN1C1. Enzymes of this class are important factors for the biosynthesis of various types of N-linked oligosaccharide structures. Inhibition of these structures by kifunensine can interfere with cell-to-cell adhesion, targeting of lysosomal hydrolases to lysosomes, and clearance of asialoglycoproteins from the serum.


Suppliers

Santa Cruz Biotechnology, Inc.
201364
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Prices & Availability




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Properties for Kifunensine

Molecular Weight:
232.19 g·mol−1
Density:
1.85 g/cm3
Melting point:
>280°C
Solubility:
Soluble in water (double-distilled, 50 mM), ethanol, DMF and DMSO.
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Safety & Transport Information

Storage temperature :
-20°C
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Alternative Distributors of [Kifunensine]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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Downloads

Mol File:
-/-
MSDS:
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