Kenpaullone | CAS 142273-20-9 | Chemical-Suppliers

Element: kenpaullone

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C-S » Chemicals » kenpaullone-PX502336

Identification

Kenpaullone

CAS:

142273-20-9

EINECS:

Molecular Formula:

C₁₆H₁₁BrN₂O

MDL:

MFCD02683595

SMILES:

C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)Br

Synonym:

9-bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5h)-one ; 9-bromo-7,12-dihydro-5h-indolo[3,2-d][1]benzazepin-6-one ; kenpaullone 9-bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5h)-one ; kenpaullon ; 9-bromopaullone ; 8-bromo-7,12-dihydro-indolo[3,2-d][1]-benzazepin-6(5h)-one ; kenpaullone ; 9-bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5h)-one, nsc 664704 ; nsc-664704

Description

Kenpaullone is an ATP-competitive inhibitor of several CDKs (cyclin-dependent kinases) as well as GSK-3β (glycogen synthase kinase 3β). It has been shown to inhibit GSK-3 with an IC₅₀ value of 0.23 μM and CDK1/cyclin B, CDK2/cyclin A, CDK5/p25, and lymphocyte kinase with IC₅₀ values of 0.4, 0.68, 0.85, and 0.47 μM, respectively. Due to the compound's activity, Kenpaullone is useful in the study of cell cycle regulators. Kenpaullone is an inhibitor of cyclin E, ERK 2 and p35.

Suppliers

Aea.ltd

A77154

Xiamen Equation Chemical Co.,Ltd

XECC3521760

CSNpharm, Inc.

CSN11250

BOC Sciences

BS132396

Leap Chem Co., Ltd

LC198594

Santa Cruz Biotechnology, Inc.

200643

Dayang Chem (Hangzhou) Co.,Ltd.

DC3411364

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CAS equal suppliers

9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one

Haihang Industry Co., Ltd.

HI889226676

Indolo[3,2-d][1]benzazepin-6(5h)-one, 9-bromo-7,12-dihydro-

Angene International Limited

AGN-PC-0JK6OL

KENPAULLONE;8-BROMO-7,12-DIHYDRO-INDOLO[3,2-D][1]-BENZAZEPIN-6(5H)-ONE;KENPAULLONE;NSC-664704;9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one, NSC 664704

3B (Wuhan) Scientific Corporation

386064258192

Prices & Availability

Data is processed

Properties for Kenpaullone

Molecular Weight:

327.18 g·mol−1

Density:

~1.6 g/cm³ (Predicted)

Melting point:

>300 °C (dec.)

Boiling point:

~613.0° C at 760 mmHg (Predicted)

Solubility:

DMSO: 18 mg/mL, clear, yellow

Safety & Transport Information

Risk Codes:

R36/37/38 - Irritating to eyes, respiratory system and skin

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing

Hazard Symbols:

Storage temperature :

2-8°C

Alternative Distributors of [Kenpaullone]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Downloads

Mol File:

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MSDS:

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KENPAULLONE;8-BROMO-7,12-DIHYDRO-INDOLO[3,2-D][1]-BENZAZEPIN-6(5H)-ONE;KENPAULLONE;NSC-664704;9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one, NSC 664704