NFκB Activation Inhibitor III

NF-κB Activation Inhibitor III is a thiazoloamide compound experimentally shown to inhibit TNF-α-stimulated NF-κB activation and MMP-9 in HT1080 upregulation. This upregulation corresponds to a concomitant inhibition of TNF-α-dependent cellular invasion. This compound has not been shown to affect the TNF-α-induced AP-1, occurring downstream of p38 activation.