CR8, (R)-Isomer | CAS 294646-77-8

Element: isomer

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C-S » Chemicals » isomer-PX94815

Identification

CR8, (R)-Isomer

CAS:

294646-77-8

EINECS:

Molecular Formula:

C₂₄H₂₉N₇O

MDL:

MFCD18785641

SMILES:

CC[C@H](CO)NC1=NC2=C(C(=N1)NCC3=CC=C(C=C3)C4=CC=CC=N4)N=CN2C(C)C

Synonym:

1-Butanol, 2-[[9-(1-methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2- yl]amino]-, (2R)-

Description

CR8, (R)-Isomer is a cell-permeable (R)-DRF053 analog that acts as an ATP-binding pocket-targeting CDK/CK1 dual-specific inhibitor (IC₅₀ = 0.09, 0.072, 0.041, 0.11, 1.10, 0.18, and 0.40 μM against CDK1/B (cyclin dependent kinase 1/B), CDK2/A (cyclin dependent kinase 2/A), CDK2/E (cyclin dependent kinase 2/E), CDK5/p25 (cyclin dependent kinase 5/p25), CDK7/H (cyclin dependent kinase 7/H), CDK9/T (cyclin dependent kinase 9/T), and CK1δ/ε, respectively). (R)-CR8 inhibits CDK/CK1 more effectively than (R)-Roscovitine, while maintaining similar selectivity profile over other types of kinases (IC₅₀ = 3.6, 3.6, and 12.0 μM against Dyrk1A, Erk2, and GSK-3α/&beta (glycogen synthase kinase-3α/β), respectively). Both (R)-CR8 and (S)-enantiomers are much more effective than (R)-Roscovitine in apoptosis induction in cell cultures.

Suppliers

Santa Cruz Biotechnology, Inc.

311306

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(R)-CR8

Santa Cruz Biotechnology, Inc.

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Amadis Chemical Company Limited

ACCL4342170

(R)-2-((9-Isopropyl-6-((4-(pyridin-2-yl)benzyl)amino)-9H-purin-2-yl)amino)butan-1-ol

BLD Pharmatech Ltd

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(2R)-2-[[9-(1-Methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-1-butanol

Leap Chem Co., Ltd

LC3175295256

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Properties for CR8, (R)-Isomer

Molecular Weight:

431.5 g·mol−1

Safety & Transport Information

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Alternative Distributors of [CR8, (R)-Isomer]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Shanghai Boyle Chemical Co., Ltd.