Indomethacin | CAS 53-86-1 | Chemical-Suppliers

Element: indomethacin

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C-S » Chemicals » indomethacin-PX78576

Identification

Indomethacin

CAS:

53-86-1

EINECS:

200-186-5

Molecular Formula:

C₁₉H₁₆ClNO₄

MDL:

MFCD00057095

SMILES:

COC1=CC2=C(C=C1)N(C(=O)C1=CC=C(Cl)C=C1)C(C)=C2CC(O)=O

Synonym:

tannex ; vonum ; indacin ; lausit ; dolovin ; inacid ; amuno ; indocin ; catlep ; bonidin

Description

Indomethacin, an antiinflammatory agent, inhibits Cox-1 and Cox-2 (cyclooxygenases) with selectivity for Cox-1 (IC₅₀ of 230 nM) over Cox-2 (IC₅₀ of 630 nM). Additionally, indomethacin displays adipogenic actions via binding and activation of PPARγ (peroxisome proliferator-activated receptor γ), a ligand-activated transcription factor known to play an important role in adipogenesis. Other studies show indomethacin to stabilize cholesterol-dependent nanoclusters and enhance phase separation in biological membranes, which could consequentially effect plasma membrane assembled cell signaling cascades. Indomethacin is an activator of PPAR α.

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Carbone Scientific Co., Ltd.

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AK Scientific, Inc.

AS228684

Xingrui Industry Co., Limited

XIL3481392

Santa Cruz Biotechnology, Inc.

200503

Dayang Chem (Hangzhou) Co.,Ltd.

DC3721488

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Prices & Availability

Data is processed

Properties for Indomethacin

Molecular Weight:

357.79 g·mol−1

Density:

1.33 g/cm³

Melting point:

155-162 °C

Solubility:

ethanol: 50 mg/mL, clear, yellow-green

Hazard Statements

GHS06
Toxic

Acute toxicity (oral, dermal, inhalation), categories 1, 2, 3

Safety & Transport Information

Risk Codes:

R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed
R28 - Very toxic if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
R39/23/24/25 - Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S28 - After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
S36 - Wear suitable protective clothing
S36/37 - Wear suitable protective clothing and gloves
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)

Hazard Classes:

6.1

Hazard Symbols:

T+, Xi, T

Storage temperature :

Store at RT

RID/ADR certification :

UN 2811 6.1 / PG 1

Alternative Distributors of [Indomethacin]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified