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Indirubin

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Formula: C16H10N2O2
CAS: 479-41-4
search Element: indirubin
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Identification

Structural Formula
Indirubin
CAS:
479-41-4
EINECS:
Molecular Formula:
C16H10N2O2
MDL:
SMILES:
C1=CC=C2C(=C1)/C(=C/3C(=O)C4=CC=CC=C4N3)/C(=O)N2
Synonym:
2-ylidene)-1,3-dihydro- ; indirubin (rg) ; nsc105327 ; indigo red ; indigopurpurin ; c.i.73200 ; c.i.75790 ; indirubin , couroupitine b ; couroupitine b ; indirubin


Description

Indirubin, also known as isoindigotin, is an inhibitor of cyclin-dependent kinases (CDK1/cyclin B (IC50 = 10µM), CDK2/cyclin A (IC50 = 2.2µM), CDK2/cyclin E (IC50 = 7.5µM), CDK4/cyclin D1 (IC50 = 12µM), CDK5/p35 (IC50 = 5.5µM)) and of GSK-3β (IC50 = 600nM). Studies investigating functional isoindigos show that they have the ability to disrupt cell growth and proliferation. The compound is a potent aryl hydrocarbon receptor ligand and is found in human urine and fetal bovine serum. Synthesized isoindigo-based oligothiophenes are used to study heterojunction solar cells. Shown to inhibit allergic contact dermatitis by regulating T helper mediated immune system in a DNCB-induced model.


Suppliers

Chengdu Pufeide Biotech. Co., Ltd
CPB2971188
+
H&Z Industry Co.,Ltd
HIC180720
+
Chemlyte Solutions
CS162486
+
Indofine Chemical Co, Inc.
06-713
CSNpharm, Inc.
CSN19364
Carbone Scientific Co., Ltd.
CS252756
+
Xingrui Industry Co., Limited
XIL2611044
+
BOC Sciences
BS108324
+
Leap Chem Co., Ltd
LC162486
+
Santa Cruz Biotechnology, Inc.
201531
Dayang Chem (Hangzhou) Co.,Ltd.
DC2791116
+
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CAS equal suppliers

3-(1,3-dihydro-3-oxo-2h-indol-2-ylidene)-1,3-dihydro-2h-indol-2-on
Capot Chemical Co., Ltd.
35044
3-(1,3-Dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-2H-indol-2-one
Salsbury Chemicals, Inc.
SC1447243416
2H-indol-2-one, 3-(1,3-dihydro-3-oxo-2h-indol-2-ylidene)-1,3-dihydro-
Angene International Limited
AGN-PC-0LPZ6R

Prices & Availability




Data is processed


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Properties for Indirubin

Molecular Weight:
262.26 g·mol−1
Solubility:
Soluble in DMSO(warmed) (>2 mg/ml).
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Hazard Statements

GHS07

GHS03
Harmful
  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    - Respiratory tract irritation
    - Narcotic effects
    • Not used
  • with the "skull and crossbones" pictogram
  • for skin or eye irritation if:
  • the "corrosion" pictogram also appears
  • the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

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Alternative Distributors of [Indirubin]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Cfm Oskar Tropitzsch GmbH | BOC Sciences | Jinan Great Chemical Co., Ltd. | Gihi Chemicals Co., Limited | 3B Scientific Corporation | Excenen Pharmatech Co., Ltd. | HuaiBei SanHe Developing Co., Ltd. | Shanghai Tauto Biotech Co., Ltd. | Jinan Haohua Industry Co., Ltd. | Nantong Chem-Tech. (Group) Co., Ltd. | ChengDu KaiXin Technology Development Co., Ltd. | Chengdu Qiaofeng Technological Development Co., Ltd. | ShangHai Biochempartner Co., Ltd. | Shanxi Zishan Natural Technology Co., Ltd. | East Chemical Industry Co., Ltd. | Aopharm

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MSDS:
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