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N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO)

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Formula: C7H15N3O2.HCl
CAS: 150403-88-6

Identification

Structural Formula
N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO)
CAS:
150403-88-6
EINECS:
Molecular Formula:
C7H15N3O2.HCl
MDL:
MFCD00153817
SMILES:
CC(=NCCC[C@@H](C(=O)O)N)N.Cl
Synonym:
nδ-(iminoethyl)-l-ornithine ; l-nio hydrochloride, l-ornithine ω-acetamidine hydrochloride ; n(5)-(1-iminoethyl)-l-ornithine hcl (l-nio) ; l-ornithine ψ-acetamidine hydrochloride


Description

N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO), is an inhibitor of NOS3 (nitric oxide synthase) in the vascular endothelium that can halt endothelium-dependent relaxation induced by acteylcholine and cause endothelium-dependent contraction in aortic rings. Mechanistic studies have noted that L-NIO inhibits Ca2+-dependent NOS3 (eNOS). The same experiment on rat aorta has shown L-NIO to display a capacity to induce a dose-dependent increase in mean systemic arterial blood pressure. In addition, research has shown L-NIO to be the most potent inhibitor of the neutrophil and J774 enzymes compared to its analogues L-NMMA, L-NAME, and L-NNA.


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Santa Cruz Biotechnology, Inc.
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CAS equal suppliers

N(5)-(1-Iminoethyl)-L-ornithine hydrochloride
Santa Cruz Biotechnology, Inc.
SCB675027000

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Properties for N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO)

Molecular Weight:
209.675 g·mol−1
Melting point:
225-226 °C
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Safety & Transport Information

Risk Codes:
R36/37/38 - Irritating to eyes, respiratory system and skin
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
Hazard Symbols:
Xi
Hazard symbol Xi
Storage temperature :
Hygroscopic, -20 °C Freezer, Under Inert Atmosphere
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Alternative Distributors of [N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO)]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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MSDS:
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