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Imatinib mesylate

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Formula: C29H31N7O.CH4O3S
CAS: 220127-57-1
search Element: imatinib mesylate
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Identification

Structural Formula
Imatinib mesylate
CAS:
220127-57-1
EINECS:
Molecular Formula:
C29H31N7O.CH4O3S
MDL:
MFCD04307699
SMILES:
CS(O)(=O)=O.CN1CCN(CC2=CC=C(C=C2)C(=O)NC2=CC=C(C)C(NC3=NC=CC(=N3)C3=CC=CN=C3)=C2)CC1
Synonym:
tinib mesylate ; genfatinib ; gleevec ; st-1571 mesylate ; cgp54148b ; glivec ; cgp 57148 ; gleevac ; cgp-57148b ; sti-571


Description

Imatinib mesylate is a small molecule that inhibits the c-Abl protein-tyrosine kinase, a kinase specifically important for proliferation of chronic myelogenous leukemia (CML). A translocation event between chromosomes 9 and 22 generates the Philadelphia chromosome, which then produces the Bcr-Abl fusion protein with aberrant kinase activity that promotes rapid cell proliferation. Imatinib binds up this crucial kinase, halting CML related growth. Imatinib mesylate has further been displayed to inhibit PDGFR and tyrosine kinases associated with c-Kit.


Suppliers

H&Z Industry Co.,Ltd
HIC6802720
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Ambeed, Inc.
A265691
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Shandong SanYoung Industry Co., Ltd
SSI11904760
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Chemlyte Solutions
CS6121836
+
Aozeal Certified Standards (AOCS), Inc.
I0002.00
+
Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)
CI23469384
+
Shandong Minglang Chemical Co., Ltd
SMC11904760
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Autech Industry Co.,Limited
AIC9183672
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Hangzhou Cherry Pharmaceutical Technology Co., Ltd.
HCPT17348670
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Arcadia Biotechnology
AB7142142
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Xiamen Equation Chemical Co.,Ltd
XECC10885440
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Sancai Industry Co.,Ltd.
SIC8163264
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Aecochem Corp.
AC4761428
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CSNpharm, Inc.
CSN16807
Finetech Industry Limited
FIL8503400
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Carbone Scientific Co., Ltd.
CS9522856
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AK Scientific, Inc.
AS6461938
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Simagchem Corporation
SC7142142
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Xingrui Industry Co., Limited
XIL9863944
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Capot Chemical Co., Ltd.
18211
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BOC Sciences
BS4081224
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Amadis Chemical Company Limited
ACCL10545270
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Santa Cruz Biotechnology, Inc.
202180
Dayang Chem (Hangzhou) Co.,Ltd.
DC10544216
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Prices & Availability




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Properties for Imatinib mesylate

Molecular Weight:
589.71 g·mol−1
Melting point:
214-224°C
Solubility:
Soluble in water (200 mg/ml), ethanol (~0.2 mg/ml), DMSO (200 mg/ml), DMF (~10 mg/ml), and methanol (sparingly).



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