16(S)-Iloprost | CAS 74843-14-4 | Chemical-Suppliers

Element: iloprost

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C-S » Chemicals » iloprost-PX65658

Identification

16(S)-Iloprost

CAS:

74843-14-4

EINECS:

Molecular Formula:

C₂₂H₃₂O₄

MDL:

MFCD18432681

SMILES:

CC#CC[C@H](C)[C@@H](/C=C/[C@H]1[C@@H](C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/

Synonym:

Description

16(S)-Iloprost potently inhibits platelet aggregation with an IC₅₀ value of 3.5 nM. Iloprost is a second generation structural analog of prostacyclin (PGI2) with roughly ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. This compound binds with equal affinity to the recombinant human EP1 and IP receptors with a K_i value of 11 nM. Most preparations of iloprost contain 16(S) and 16(R) stereoisomers.