Ac-IETD-AFC | CAS 211990-57-7 | Chemical-Suppliers

Element: ietd

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C-S » Chemicals » ietd-afc-PX89376

Identification

Ac-IETD-AFC

CAS:

211990-57-7

EINECS:

Molecular Formula:

C₃₁H₃₈ F₃ N₅ O₁₂

MDL:

MFCD02094703

SMILES:

CCC(C)C(C(=O)NC(CCC(=O)O)C(=O)NC(C(C)O)C(=O)NC(CC(=O)O)C(=O)NC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F)NC(=O)C

Synonym:

n-acetyl-ile-glu-thr-asp-(7-amino-4-trifluoromethylcoumarin) ; n-acetyl-ile-glu-thr-asp-7-amino-4-trifluoromethylcoumarin afc ; n-acetyl-l-isoleucyl-l-alpha-glutamyl-l-threonyl-n-[2-oxo-4-(trifluoromethyl)-2h-1-benzopyran-7-yl]-l-alpha-asparagine ; ac-ietd-afc ; ac-ile-glu-thr-asp-7-amino-4-trifluoro-methylcoumarin ; l-a-asparagine,n-acetyl-l-isoleucyl-l-a-glutamyl-l-threonyl-n-[2-oxo-4-(trifluoromethyl)-2h-1-benzopyran-7-yl]-(9ci) ; ac-ile-glu-thr-asp-afc ; granzyme b substrate i, colorimetric ; m.w. 729.66 c31h38f3n5o12 ; caspase-8 fluorogenic substrate ; caspase 8 substrate 1f, fluorogenic

Description

Ac-IETD-AFC is a fluorogenic substrate for caspase-8/caspase-3 processing enzyme and granzyme B. It is also a substrate for caspase-10. The IETD sequence is based on caspase-3 proenzyme cleavage site.