10Z-Hymenialdisine | CAS 82005-12-7

Element: hymenialdisine

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C-S » Chemicals » hymenialdisine-PX92403

Identification

10Z-Hymenialdisine

CAS:

82005-12-7

EINECS:

Molecular Formula:

C₁₁H₁₀BrN₅O₂

MDL:

MFCD04037007

SMILES:

C1CNC(=O)C2=C(/C1=C/3C(=O)N=C(N3)N)C=C(N2)Br

Synonym:

pyrrolo[2,3-c]azepin-8(1h)-one,4-(2-amino-1,5-dihydro-5-oxo-4h-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydro-,(z)- ; hd ; (z)-hymenialdisine ; hymenialdesine ; (z)-4-(2-amino-1,5-dihydro-5-oxo-4h-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydro-pyrrolo[2,3-c]azepin-8(1h)-one ; (4z)-4-(2-amino-1,5-dihydro-5-oxo-4h-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydro-pyrrolo[2,3-c]azepin-8(1h)-one ; 4-(2-amino-4-oxo-2-imidazolidin-5-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one ; anti-hd antibody produced in mouse ; hymenialdisine ; 10z-hymenialdisine

Description

10Z-Hymenialdisine is a novel alkaloid isolated from Axinella damicornis. It is known to act as an ATP-competitive kinase inhibitor. It exhibits inhibitory activity against cyclin-dependent kinases, CK1 and GSK-3β. It has also been shown to block the phospho 10Z-Hymenialdisine is an inhibitor of Cdk1, Cdk2, Cdk3, Cdk5, cyclin A, cyclin B, cyclin E, MEK-1 and p35. 10Z-Hymenialdisine is an inhibitor of MARK.