Hygromycin B solution | CAS 31282-04-9

Element: hygromycin solution

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Identification

Hygromycin B solution

CAS:

31282-04-9

EINECS:

250-545-5

Molecular Formula:

C₂₀H₃₇N₃O₁₃

MDL:

MFCD06795479

SMILES:

CN[C@H]1C[C@H]([C@@H]([C@H]([C@@H]1O)O[C@H]2[C@@H]3[C@H]([C@H]([C@H](O2)CO)O)OC4(O3)[C@@H]([C@@H]([C@H]([C@H](O4)[C@H](CO)N)O)O)O)O)N

Synonym:

hygromix-8 ; hygromix2.4 ; hyaromycin b ; hygrovetine ; hygromix ; 2-3)-o-b-d-talopyranosyl-(1® ; hygromycin b ; hygromix 2.4 ; hygrovetin ; d-streptamine,o-6-amino-6-deoxy-l-glycero-d-galacto-heptopyranosylidene-(1® ; antihelmycin ; 5)-2-deoxy-n3-methyl- ; 950u/mg ; hydromycinb ; hygromycinb (7ci)

Description

Hygromycin B is an aminoglycoside antibiotic substance naturally produced by Streptomyces hygroscopicus, which also shows anthelmintic activity. Hygromycin B has been shown to effectively inhibit translocation of mRNA and tRNAs on the ribosome in both bacteria and eukaryotes and also has a subtle effect on decoding fidelity as it slightly increases aminoacyl tRNA (A-site tRNA) affinity. Suitable for the selection of cells transfected with Escherichia coli hygromycin resistance gene (hyg or hph), as well as for the maintenance of the Hygromycin phenotype of resistant cells. Consistent with its more specific effect on translocation, hygromycin B exhibits monophasic inhibition of polypeptide synthesis, suggesting that it binds to a single site on the ribosome.

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Santa Cruz Biotechnology, Inc.

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Prices & Availability

Data is processed

Properties for Hygromycin B solution

Molecular Weight:

527.60 g·mol−1

Density:

1.67 g/cm3

Melting point:

160-180 °C

Boiling point:

897.6 °C at 760 mmHg

Flash point:

496.7 °C

Solubility:

H₂O: 50 mg/mL As a stock solution. Stock solutions should be stored at 2-8 °C. Stable at 37 °C for 30 days.

Physical Description:

amorphous solid or tan powder.

Transport Information:

UN 3462 6.1/PG 1

Hazard Statements

GHS05
Corrosive

Corrosive to metals, category 1

GHS06
Toxic

Acute toxicity (oral, dermal, inhalation), categories 1, 2, 3

GHS08
Health hazard

Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A, 1B, 2
Carcinogenicity, categories 1A, 1B, 2
Reproductive toxicity, categories 1A, 1B, 2
Specific target organ toxicity following single exposure, categories 1, 2
Specific target organ toxicity following repeated exposure, categories 1, 2
Aspiration hazard, categories 1, 2

Safety & Transport Information

Risk Codes:

R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed
R26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed
R36 - Irritating to eyes
R40 - Limited evidence of a carcinogenic effect
R41 - Risk of serious damage to eyes
R42/43 - May cause sensitization by inhalation and skin contact

Safety Codes:

S22 - Do not breathe dust
S23 - Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer)
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S28 - After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
S36 - Wear suitable protective clothing
S36/37 - Wear suitable protective clothing and gloves
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)

Hazard Symbols:

T+, Xn, T

Storage temperature :

2-8°C

RID/ADR certification :

UN 3462 6.1 / PG 1

Alternative Distributors of [Hygromycin B solution]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

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MSDS:

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