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(Z)-4-Hydroxytamoxifen

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Formula: C26H29NO2
CAS: 68047-06-3
search Element: hydroxytamoxifen
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Identification

Structural Formula
(Z)-4-Hydroxytamoxifen
CAS:
68047-06-3
EINECS:
Molecular Formula:
C26H29NO2
MDL:
MFCD00278780
SMILES:
CC/C(=C(C1=CC=C(C=C1)O)/C2=CC=C(C=C2)OCCN(C)C)/C3=CC=CC=C3
Synonym:
(z)-4-oht ; trans-4-hydroxytamoxifen ; cis-4-hydroxytamoxifen ; hydroxytamoxifen ; ici79,280 ; 4-oht ; c05011 ; see h9711, h9712, or h9716 ; tamoxifen, 4-hydroxy- ; 4-hydroxytamoxifen


Description

4-Hydroxytamoxifen is an active metabolite of tamoxifen, an anti-estrogen agent. This compound has been reported to irreversibly inhibit purified protein kinase C (PKC) in vitro through oxidative inactivation of the catalytic domain. Additionally, microsomal activation of 4-hydroxytamoxifen has been reported to lead to the formation of DNA adducts in vitro. The formation of these DNA adducts were also reported to be dependent on the cofactor utilized for microsomal activation. (Z)-4-Hydroxytamoxifen has also been shown to inhibit lipid peroxidation.


Suppliers

Santa Cruz Biotechnology, Inc.
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Prices & Availability




Data is processed


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Properties for (Z)-4-Hydroxytamoxifen

Molecular Weight:
387.51 g·mol−1
Density:
1.09 g/cm3 (Predicted)
Melting point:
105-107 °C
Boiling point:
514.38° C at 760 mmHg (Predicted)
Solubility:
95% ethanol: 20 mg/mL
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Safety & Transport Information

Risk Codes:
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed
R63 - Possible risk of harm to the unborn child
Safety Codes:
S22 - Do not breathe dust
S23 - Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer)
S36 - Wear suitable protective clothing
Hazard Symbols:
Xn
Hazard symbol Xn
Storage temperature :
2-8°C
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Alternative Distributors of [(Z)-4-Hydroxytamoxifen]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Clearsynth Canada INC.

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Downloads

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